Table 3 Univariate and multivariate Cox analyses of CSS in training set

Age (years, > 60/≤60)

0.925 (0.687–1.245)

0.606

Gender (male/female)

0.872 (0.640–1.188)

0.386

Tumor length (cm, > 3.0/≤3.0)

1.266 (0.919–1.745)

0.149

 middle/upper

1.175 (0.609–2.266)

0.631

 lower/upper

1.149 (0.598–2.209)

0.677

Vessel invasion (yes/no)

1.657 (1.149–2.388)

0.007

Perineural invasion (yes/no)

1.564 (1.116–2.193)

0.009

 moderate/well

1.146 (0.745–1.762)

0.534

 poor/well

1.334 (0.796–2.236)

0.274

 II/I

1.723 (1.150–2.582)

0.008

1.814 (1.200–2.743)

0.005

 III/I

2.555 (1.734–3.765)

< 0.001

1.981 (1.317–2.980)

< 0.001

Adjuvant treatment (yes/no)

1.099 (0.796–1.516)

0.567

PNI (> 47.5/≤47.5)

0.534 (0.398–0.717)

< 0.001

SII (> 588/≤588)

1.816 (1.334–2.471)

< 0.001

1.445 (1.046–1.997)

0.026

 1/0

1.865 (1.272–2.735)

0.001

1.938 (1.310–2.868)

0.001

 2/0

3.043 (1.960–4.725)

< 0.001

2.757 (1.762–4.315)

< 0.001

 3/0

5.744 (3.090–10.676)

< 0.001

4.779 (2.499–9.140)

< 0.001

 1/0

2.092 (1.507–2.906)

< 0.001

 2/0

3.435 (2.158–5.469)

< 0.001

 1/0

1.637 (1.207–2.221)

0.002

 2/0

1.914 (1.084–3.379)

0.025