Table 2 Univariate and multivariate analyses of prognostic factors for PFS and OS

Age, years

≥50

0.49 (0.30–0.80)

0.004

0.45 (0.27–0.76)

0.002

0.55 (0.31–0.97)

0.040

0.58 (0.33–1.04)

0.065

Sex

Female

1.57 (0.85–2.89)

0.152

0.94 (0.44–2.00)

0.863

HBsAg

Positive

1.02 (0.51–2.08)

0.947

1.10 (0.47–2.60)

0.823

Child Pugh class

B

1.19 (0.59–2.40)

0.636

1.83 (0.89–3.79)

0.103

BCLC stage

C

1.40 (0.63–3.12)

0.413

Extrahepatic metastasis

Yes

1.23 (0.75–2.01)

0.418

1.32 (0.74–2.33)

0.346

AFP level ≥ 400μg/ml

Yes

1.02 (0.62–1.67)

0.941

1.01 (0.57–1.78)

0.981

Prior systemic treatment

Yes

2.00 (0.98–4.06)

0.057

1.49 (0.70–3.19)

0.304

Prior TACE

Yes

Maximum diameter of ≥5 cm

Yes

1.45 (0.78–2.69)

0.236

1.86 (0.87–3.98)

0.110

Tumor occupation ≥50%

Yes

2.50 (1.49–4.18)

< 0.001

2.66 (1.57–4.49)

< 0.001

3.98 (2.19–7.22)

< 0.001

3.90 (2.14–7.12)

< 0.001

Invasion with Vp4

Yes

0.85 (0.50–1.43)

0.528

0.95 (0.52–1.72)

0.855