Table 2 Main decision-tree inputs
Input | Reference | |
|---|---|---|
Invalid results and positivity rate of selected biomarkers | ||
EGFR (% positive / % invalid) | 13.6% / 1.70% | [15] |
ALK (% positive / % invalid) | 3.4% / 2.60% | [15] |
ROS1 (% positive / % invalid) | 1.0% / 3.30% | [15] |
PD-L1 (TPS ≥ 50%) (% positive / % invalid) | 32.5% / 1.00% | Expert panel / [15] |
Probability of re-biopsy | ||
Percentage of invalid results re-biopsied | 33.3% | Expert panel |
ROS1 determination strategies | ||
IHC | 10.0% | Expert panel |
FISH | 30.0% | Expert panel |
REFLEX to FISH | 55.0% | Expert panel |
NGS | 5.0% | Expert panel |