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Table 7 Bivariate and multivariate logistic regression analyses of ENE using surgically resected specimens

From: Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion

 

Bivariate

Multivariate

 

Odds ratio

95% CI

p

Odds ratio

95% CI

p

All (n = 186)

      

DR-I

1.71

0.52 − 5.63

0.38

   

TB-H

3.30

1.15 − 9.60

0.03

3.14

1.25 − 7.91

 < 0.001

TILs-L

1.74

0.59 − 5.12

0.31

   

pDOI > 5 mm

1.47

0.18 − 11.7

0.71

   

pDOI > 10 mm

6.90

1.49 − 31.9

0.01

8.05

2.62 − 24.7

 < 0.001

Progressive (n = 94)

      

DR-I

1.04

0.29 − 3.68

0.94

   

TB-H

1.04

1.37 − 13.3

0.01

   

TILs-L

1.59

0.50 − 5.02

0.42

   

pDOI > 5 mm

1.06

0.04 − 27.4

0.97

   

pDOI > 10 mm

1.40

0.13 − 14.4

0.67

   

Metastasis (n = 56)

      

DR-I

0.58

0.13–2.66

0.48

   

TB-H

5.70

1.39 − 23.4

0.02

   

TILs-L

2.37

0.64 − 9.94

0.20

   

pDOI > 5 mm

0.31

0.02 − 4.40

0.38

   

pDOI > 10 mm

2.99

0.50 − 17.9

0.23

   
  1. CI Confidence interval, DR-I Immature desmoplastic reaction, TB-H High tumor budding, TILs-L Low-grade tumor-infiltrating lymphocytes, pDOI pathological depth of invasion, ENE Extranodal extension
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BMC Cancer

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