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Table 1 Patients’ demographics

From: Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion

 

All patients (n = 186)

Early OSCC (n = 92)

Progressive OSCC (n = 94)

Characteristics

No. of patients

%

No. of patients

%

No. of patients

%

Sex

Female

71

(38.1)

36

(39.1)

35

(37.2)

Male

115

(61.8)

56

(60.9)

59

(62.8)

Age, years

Mean age

68.9 (range, 31 − 91)

69 (range, 31 − 91)

68.6 (range, 38 − 87)

 ≥ 64

57

(30.6)

27

(29.3)

30

(31.9)

 < 64

129

(69.4)

65

(70.7)

64

(68.1)

High-risk HPV exposure

No

186

(100)

92

(100)

94

(100)

Anatomical site

Palate

4

(2.1)

4

(4.3)

0

(0)

Oral floor

3

(1.6)

2

(2.2)

1

(1.1)

Gingiva

29

(15.6)

4

(4.3)

25

(26.6)

Tongue

129

(69.3)

67

(72.8)

62

(66.0)

Buccal mucosa

21

(11.3)

15

(16.3)

6

(0)

DOI

 ≤ 5 mm

63

(33.9)

58

(63.0)

5

(5.3)

 > 5 mm

123

(66.1)

34

(40.0)

89

(94.7)

DOI

 ≤ 10 mm

102

(54.9)

92

(100)

10

(10.6)

 > 10 mm

84

(45.2)

0

(0)

84

(9.4)

LyV

Negative

73

(39.2)

54

(58.7)

19

(20.2)

Positive

113

(60.8)

38

(41.3)

75

(79.8)

ENE

Negative

159

(85.5)

90

(97.8)

69

(73.4)

Positive

27

(14.5)

2

(2.2)

25

(26.6)

pT

1, 2

92

(49.5)

92

(100)

0

(0)

3, 4

94

(50.5)

0

(0)

94

(100)

pN

0

128

(68.8)

83

(90.2)

45

(47.9)

1

16

(8.6)

4

(4.3)

12

(64.5)

2, 3

42

(22.6)

5

(5.4)

37

(19.9)

  1. OSCC Oral squamous cell carcinoma, HPV Human papilloma virus, DOI Depth of invasion, LyV Lymphovascular invasion, ENE Extranodal extension, pT pathological T, pN pathological N. DOI included both cDOI and pDOI because the cohorts of clinical DOI and pathological DOI were matched 100% (concordance rate = 100%); cutoff points were DOI ≤ 5 mm/DOI > 5 mm and DOI ≤ 10 mm/DOI > 10 mm