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Fig. 1 | BMC Cancer

Fig. 1

From: Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion

Fig. 1

Definition and measurement of ENE and evaluation of DR, TILs, and TB at ENE. a Diameters of the extent of ENE and tumor deposits were recorded as the widest length of the dissected lymph nodes of the same patients (H&E staining, × 15). b, c The ENE region shows immature stroma, low-grade TILs, and nine budding areas (arrows: budding) (H&E staining, b, × 100; c, × 400). DR, desmoplastic reaction; ENE, extranodal extension; H&E, hematoxylin and eosin; TB, tumor budding; TILs, tumor-infiltrating lymphocytes

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