Fig. 4

Abbreviations: (A) TMB Tumour mutation burden (mutations / MB); Case 1 and 17: do not acquire sufficient sequencing depth due to DNA degradation; Case 5, 6 and 9: do not detect genetic mutations; Case 23, 24 and 30: except owing to diagnosed as combined LCNEC; (B) The 42 genes consisted by the selected 26 tumour samples (due to DNA degradation, case 1 and 17 did not acquire a sufficient sequencing depth, meanwhile, for case 2, 5, 6 and 9 we did not detect any genetic mutations) involved: 40 genes which occurred more than one time and 2 genes which the atypical carcinoid samples involved; (C)The abscissa represents the number of cases involved in; The ordinate represents the involved mutation paths; The pathways which involved at least there of the top ten genes: Pathways in cancer; Hepatocellular carcinoma; PI3K-Akt signaling pathway; MicroRNAs in cancer; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Breast cancer; Cellular senescence; Central carbon metabolism in cancer; Melanoma; Prostate cancer; Autophagy-animal; Glioma; Apoptosis; p53 signaling pathway; Small cell lung cancer; mTOR signaling pathway; Metabolic pathways; Endometrial cancer; Gastric cancer and Cell cycle; The other 6 paths reported usually been seen in LCNEC: Ras signaling pathway, Non-small cell lung cancer, Focal adhesion, JAK-STAT signaling pathway, MAPK signaling pathway, ErbB signaling pathway