Table 3 Results of subgroup analyses on prognostic effects of CRC patients
Comparisons (vs LODDS0) | OS | DFS | ||||
|---|---|---|---|---|---|---|
No. of studies | HR (95% CI) | Heterogeneity | No. of studies | HR (95% CI) | Heterogeneity | |
I2 (%) | I2 (%) | |||||
TOTAL studies | ||||||
LODDS1 | 9 | 1.77 (1.38, 2.28) | 18.3 | 4 | 1.82 (1.23, 2.68) | 35 |
LODDS2 | 9 | 3.49 (2.88, 4.23) | 0 | 3 | 4.53 (3.14, 6.55) | 0 |
Yearc | ||||||
> Median | ||||||
LODDS1 | 4 | 1.53 (1.07, 2.21) | 25.9 | 1 | 2.73 (1.72, 4.34) | – |
LODDS2 | 4 | 3.51 (2.59, 4.76) | 0 | 1 | 4.56 (2.91, 7.16) | – |
≤ Median | ||||||
LODDS1 | 5 | 2.06 (1.46, 2.92) | 7.1 | 3 | 1.44 (0.99, 2.09) | 0 |
LODDS2 | 5 | 3.62 (2.56, 5.11) | 36.4 | 2 | 4.48 (2.36, 8.47) | 0 |
Country | ||||||
East Asia | ||||||
LODDS1 | 2 | 2.41 (1.27, 4.57) | 0 | 2 | 1.94 (0.97, 3.86) | 74.6 |
LODDS2 | 2 | 3.65 (2.37, 5.62) | 0 | 1 | 4.56 (2.91, 7.16) | – |
non-East Asia | ||||||
LODDS1 | 7 | 1.69 (1.27, 4.57) | 26.4 | 2 | 1.54 (0.89, 2.67) | 0 |
LODDS2 | 7 | 3.47 (2.78, 4.34) | 4.9 | 2 | 4.48 (2.36, 8.47) | 0 |
Type of cancer | ||||||
colorectal cancer | ||||||
LODDS1 | 3 | 2.21 (1.45, 3.37) | 0 | 1 | 1.54 (0.89, 2.67) | – |
LODDS2 | 3 | 3.48 (2.51, 4.84) | 0 | 1 | 4.56 (2.91, 7.16) | – |
colon cancer | ||||||
LODDS1 | 5 | 1.68 (1.14, 2.46) | 42.8 | 2 | 2.73 (1.72, 4.34) | 0 |
LODDS2 | 5 | 3.79 (2.79, 5.15) | 31 | 2 | 4.48 (2.36, 8.47) | 0 |
rectal cancer | ||||||
LODDS1 | 1 | 1.14 (0.44, 2.98) | – | 1 | 1.35 (0.80, 2.26) | – |
LODDS2 | 1 | 2.47 (1.17, 5.22) | – | – | – | – |