Fig. 6

The overexpression of TIM-1 inhibited CC cell apoptosis and modulated the levels of cell cycle- and cell apoptosis-related proteins. The percentages of apoptotic and necrotic HeLa (A, C) and SiHa (B, D) cells were determined by flow cytometry. E, F Western blotting and statistical results of differences in protein levels of cyclin D1, p53, Bcl-2, and BAX. The data represent the averages of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the MOCK and NC groups. TIM-1, T-cell immunoglobulin mucin-1; CC, cervical cancer; MOCK, blank control; NC, negative control