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Table 5  Factors associated with postoperative complicationsa after major resections with curative intent (R0 and R1); n = 1021b

From: Octogenarian patients with colon cancer – postoperative morbidity and mortality are the major challenges

Factors Unadjusted odds ratio
(95% CI)
P value Adjusted odds ratio
(95% CI)
P value
Age (years)
   < 65 1 (reference)   1 (reference)  
  65—74 1.51 (1.08 to 2.11) 0.016 1.35 (0.94 to 1.96) 0.11
  75 – 79 2.13 (1.47 to 3.08)  < 0.001 1.51 (0.99 to 2.28) 0.053
  80—84 2.83 (1.93 to 4.17)  < 0.001 1.96 (1.27 to 3.03) 0.002
  85 – 89 2.96 (1.73 to 5.03)  < 0.001 2.14 (1.18 to 3.87)  0.013
  ≥ 90 7.60 (3.11 to 18.58)  < 0.001 5.36 (2.11 to 13.61)  < 0.001
Female sex 0.99 (0.78 to 1.25) 0.95 1.15 (0.89 to 1.49) 0.28
Calendar year
  1980–1989 1 (reference)   1 (reference)  
  1990–1999 0.46 (0.32 to 0.67)  < 0.001 0.44 (0.30 to 0.66)  < 0.001
  2000–2009 0.43 (0.30 to 0.60)  < 0.001 0.50 (0.33 to 0.94) 0.001
  2010–2016 0.47 (0.33 to 0.68)  < 0.001 0.61 (0.40 to 0.94) 0.025
ASA score
  1–2 1 (reference)   1 (reference)  
  3 2.00 (1.56 to 2.56)  < 0.001 1.43 (1.08 to 1.90) 0.013
  4–5 19.07 (9.56 to 38.05)  < 0.001 10.86 (5.19 to 22.73)  < 0.001
Emergency surgery 2.51 (1.75 to 3.60) 0.001 2.30 (1.57 to 3.39)  < 0.001
Anaemia (g/dL haemoglobin)
  Female ≥ 12.0, Male ≥ 13.0 1 (reference)   1 (reference)  
  Female 10–11.9, Male 11–12.9 1.97 (1.47 to 2.64)  < 0.001 2.26 (1.64 to 3.11)  < 0.001
  Female < 10, Male < 11 4.76 (3.53 to 6.43)  < 0.001 5.61 (4.01 to 7.84)  < 0.001
Surgery duration (minutes)
  < 90 1 (reference)   1 (reference)  
  90–179 1.01 (0.73 to 1.38) 0.96 0.96 (0.67 to 1.39) 0.84
  ≥ 180 2.24 (1.48 to 3.38) 0.001 1.52 (0.89 to 2.58) 0.13
Blood loss (mL)
  0–200 1 (reference)   1 (reference)  
  201–400 1.21 (0.88 to 1.65) 0.24 1.48 (1.04 to 3.11) 0.029
  401–800 1.67 (1.20 to 2.32) 0.002 2.16 (1.45 to 3.21)  < 0.001
  > 800 3.69 (2.41 to 5.65)  < 0.001 4.13 (2.44 to 7.01)  < 0.001
  1. aComplications were classified according to Clavien-Dindo grades; bPatients included those with stages I-III colon cancer during 1980–2016