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Table 3 Factors associated with long-term relative survival in 1324 patients that survived 90 days after admission

From: Octogenarian patients with colon cancer – postoperative morbidity and mortality are the major challenges

Factors Unadjusted hazard ratio P value Adjusted hazard ratio P value
(95% CI) (95% CI)
Age (years)
  < 65 1 (reference)   1 (reference)  
  65—74 1.05 (0.81 to 1.36) 0.69 1.22 (0.94 to 1.61) 0.12
  75—79 0.93 (0.67 to 1.29) 0.66 1.16 (0.83 to 1.62) 0.37
  80 – 84 1.02 (0.71 to 1.46) 0.91 0.92 (0.64 to1.33) 0.65
  85 – 89 1.36 (0.83 to 2.25) 0.23 0.86 (0.52 to 1.42) 0.56
  ≥ 90 1.26 (0.44 to 3.60) 0.67 1.17 (0.56 to 2.47) 0.68
Female sex 1.14 (0.92 to 1.41) 0.23 1.28 (1.04 to 1.58) 0.021
Calendar year
   1980–1989 1 (reference)   1 (reference)  
  1990–1999 0.95 (0.70 to 1.29) 0.74 0.68 (0.50 to 0.93) 0.016
  2000–2009 0.69 (0.51 to 0.93) 0.016 0.55 (0.40 to 0.74)  < 0.001
  2010–2016 0.58 (0.42 to 0.82) 0.002 0.43 (0.31 to 0.61)  < 0.001
CCI 1.36 (1.20 to 1.55)  < 0.001 1.24 (1.07 to 1.43) 0.004
ASA score
  1–2 1 (reference)   1 (reference)  
  3 1.32 (1.06 to 1.65) 0.013 1.27 (0.98 to 1.64) 0.066
  4–5 4.65 (3.07 to 7.04)  < 0.001 1.95 (1.23 to 3.12) 0.005
Emergency surgery 2.09 (1.62 to 2.68)  < 0.001 1.42 (1.09 to 1.86) 0.010
TNM-stage
  I 1 (reference)   1 (reference)  
  II 1.75 (0.66 to 4.65) 0.26 1.36 (0.69 to 2.68) 0.37
  III 6.61 (2.61 to 16.74)  < 0.001 4.71 (2.47 to 8.99)  < 0.001
  IV 44.81 (17.96 to 111)  < 0.001 3.39 (1.68 to 6.85) 0.001
  Unknown 24.29 (8.67 to 68.05)  < 0.001 1.48 (0.65 to 3.34) 0.35
Treatment intent categories
  Curative intent
    Major resection 1 (reference)   1 (reference)  
    Polypectomy 1.62 (0.71 to 3.74) 0.25 3.82 (1.54 to 9.48) 0.004
  Non-curative intent
    Major resection 16.13 (12.51 to 20.80)  < 0.001 9.50 (5.94 to 15.18)  < 0.001
    Bypass/stoma 25.50 (16.59 to 39.20)  < 0.001 19.38 (10.82 to 34.69)  < 0.001
  Best supportive care 21.22 (15.74 to 28.61)  < 0.001 22.24 (12.26 to 37.28)  < 0.001
  1. Results are from a multivariable analysis; unadjusted: performed with one covariate at a time; adjusted: performed with all listed covariates included simultaneously. CCI Charlson Comorbidity Index, classified as 0, 1, or 2 +