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Table 3 Factors associated with long-term relative survival in 1324 patients that survived 90 days after admission

From: Octogenarian patients with colon cancer – postoperative morbidity and mortality are the major challenges

Factors

Unadjusted hazard ratio

P value

Adjusted hazard ratio

P value

(95% CI)

(95% CI)

Age (years)

  < 65

1 (reference)

 

1 (reference)

 

  65—74

1.05 (0.81 to 1.36)

0.69

1.22 (0.94 to 1.61)

0.12

  75—79

0.93 (0.67 to 1.29)

0.66

1.16 (0.83 to 1.62)

0.37

  80 – 84

1.02 (0.71 to 1.46)

0.91

0.92 (0.64 to1.33)

0.65

  85 – 89

1.36 (0.83 to 2.25)

0.23

0.86 (0.52 to 1.42)

0.56

  ≥ 90

1.26 (0.44 to 3.60)

0.67

1.17 (0.56 to 2.47)

0.68

Female sex

1.14 (0.92 to 1.41)

0.23

1.28 (1.04 to 1.58)

0.021

Calendar year

   1980–1989

1 (reference)

 

1 (reference)

 

  1990–1999

0.95 (0.70 to 1.29)

0.74

0.68 (0.50 to 0.93)

0.016

  2000–2009

0.69 (0.51 to 0.93)

0.016

0.55 (0.40 to 0.74)

 < 0.001

  2010–2016

0.58 (0.42 to 0.82)

0.002

0.43 (0.31 to 0.61)

 < 0.001

CCI

1.36 (1.20 to 1.55)

 < 0.001

1.24 (1.07 to 1.43)

0.004

ASA score

  1–2

1 (reference)

 

1 (reference)

 

  3

1.32 (1.06 to 1.65)

0.013

1.27 (0.98 to 1.64)

0.066

  4–5

4.65 (3.07 to 7.04)

 < 0.001

1.95 (1.23 to 3.12)

0.005

Emergency surgery

2.09 (1.62 to 2.68)

 < 0.001

1.42 (1.09 to 1.86)

0.010

TNM-stage

  I

1 (reference)

 

1 (reference)

 

  II

1.75 (0.66 to 4.65)

0.26

1.36 (0.69 to 2.68)

0.37

  III

6.61 (2.61 to 16.74)

 < 0.001

4.71 (2.47 to 8.99)

 < 0.001

  IV

44.81 (17.96 to 111)

 < 0.001

3.39 (1.68 to 6.85)

0.001

  Unknown

24.29 (8.67 to 68.05)

 < 0.001

1.48 (0.65 to 3.34)

0.35

Treatment intent categories

  Curative intent

    Major resection

1 (reference)

 

1 (reference)

 

    Polypectomy

1.62 (0.71 to 3.74)

0.25

3.82 (1.54 to 9.48)

0.004

  Non-curative intent

    Major resection

16.13 (12.51 to 20.80)

 < 0.001

9.50 (5.94 to 15.18)

 < 0.001

    Bypass/stoma

25.50 (16.59 to 39.20)

 < 0.001

19.38 (10.82 to 34.69)

 < 0.001

  Best supportive care

21.22 (15.74 to 28.61)

 < 0.001

22.24 (12.26 to 37.28)

 < 0.001

  1. Results are from a multivariable analysis; unadjusted: performed with one covariate at a time; adjusted: performed with all listed covariates included simultaneously. CCI Charlson Comorbidity Index, classified as 0, 1, or 2 +