Fig. 9

Phase contrast microscopy of pinnal-tumor derived cell lines (PTDs) and derivatives. Genotypes of the original pinnal-tumor bearing mice (Table 1) were: GFAP-Cre^tg/+;Pcdh10all^fl/fl;p53^fl/fl;Rb^fl/fl (for PTD7 and PTD25) and GFAP-Cre^tg/+;Pcdh10all^fl/fl;p53^fl/fl;Rb^+/+ (for PTD12). PTD12AD4 is a cell line derived from an allograft generated by s.c. injection of 2.5 × 10⁶ cells PTD12 (see text and Additional file 19: Fig. S9). PTD25_RS and PTD25_RL are transduced and FACS-sorted derivative populations of PTD25, rescued for Pcdh10 ablation by cDNA expression of, respectively, Pcdh10_short isoform 1 and Pcdh10_long isoform-4 (see text, Table 1 and Additional file 18: Table S12). Scale bars: 50 μm