Fig. 8
From: Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms
Immunohistochemical detection of stem cell markers, inflammation marker, and intermediate filaments in representative pinnal tumors. A, B cytoplasmic and cell surface CD44 staining (Upper right corner in B: normal epidermis with cell contact staining). C Nuclear Sox2 staining. D Nuclear NFAT1c staining. E Cytoplasmic vimentin staining. F Strong cytoplasmic desmin staining in one pinnal tumor. G Desmin staining in normal skeletal muscle of the pinna. H Cytoplasmic cytokeratin-1 staining (normal epidermis in the lower left corner). The genotype of mice in (A,B,D,E,G,H) is GFAP-Cretg/+;Pcdh10allfl/fl;p53fl/fl;Rb+/+. The mouse in (C) has genotype GFAP-Cretg/+; Pcdh10allfl/fl;p53fl/fl;Rbfl/+.The mouse in (F) has genotype GFAP-Cretg/+;Pcdh10allfl/fl;p53fl/fl; Rbfl/fl. Mouse ear tag numbers are given between brackets. All scale bars: 50 μm