Fig. 5
From: Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms
Development of medulloblastoma in GFAP-Cretg/+ transgenic mice. A,B Sagittal sections through the brain of GFAP-Cretg/+;Pcdh10allfl/fl;p53fl/fl;Rbfl/fl mice at, respectively, 16 and 23 weeks after birth. The normal cerebellum is progressively replaced by medulloblastoma. Scale bars: 5 mm. C,D Evolution of medulloblastoma-free mice with the genotypes indicated. The number of mice evaluated is indicated between brackets. Pathological evaluation was initially on the basis of typical behavioral abnormalities (tremor, uncoordinated movements, balance distortions), but confirmed for each case by dissection and histology. See Additional file 15: Table S11 for statistical analysis