Skip to main content
Fig. 14 | BMC Cancer

Fig. 14

From: Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms

Fig. 14

IPA-generated ‘Cell signalling’ network of DE genes in Pcdh10-rescued PTD25_RS versus Pcdh10-lacking PTD25 cells. The analysis was performed by the Ingenuity Pathway Analysis software (IPA, Qiagen) (see also Table 2 and legends to Fig. 13 and Additional file 24b: Fig. S13). The network graph depicts how a selection of DE genes relates to one another and to some key molecules. The genes are shown in their respective subcellular compartment, with connecting lines indicating direct (solid lines) or indirect (broken lines) relationships. DE genes with a positive z-score (activated) are colored orange, and those with a negative z-score (inhibited) are colored blue. Underneath each of the DE genes is given: baseMean value (mean of normalized counts for all PTD25 and PTD25_RS samples), log2FoldChange (condition PTD25_RS versus PTD25), padj (Benjamin-Hochberg adjusted Wald test p-value). Network shapes used here include rectangles with broken lines for growth factors, trapezia for transporters, vertical ovals for transmembrane receptors, vertical rectangles for G-protein coupled receptors, inverted triangles for kinases, triangles for phosphatases, vertical diamonds for non-kinase enzymes, circles for other molecules

Back to article page