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Table 5 Uni- and multivariate Hazard Cox regression analysis of RFS in recurrent cancer biopsiesa

From: High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy

 

Univariate

Multivariate

HR

95% CI

p-values

HR

95% CI

p-values

Age

1.00

.97 1.03

0.888

1.00

.97 1.03

0.987

CXCR4high vs CXCR4low

0.49

.25 .93

0.031

0.57

.24 1.33

0.193

Residual disease <2cm

1.13

.56 2.28

0.724

0.81

.36 1.84

0.619

Residual disease >2cm

3.67

1.62 8.31

0.002

2.48

.88 6.95

0.085

N of chemotherapy cycles

1.28

1.05 1.55

0.013

1.16

.36 3.73

0.800

FIGO IIIA

0.34

.02 5.72

0.455

0.30

.01 6.91

0.449

FIGO IIIB

0.93

.11 8.04

0.944

0.64

.07 6.27

0.705

FIGO IIIC

1.21

.16 9.03

0.851

0.85

.10 7.08

0.884

FIGO IV

1.48

.18 11.94

0.712

0.92

.10 8.22

0.939

  1. a Cut-off = 84 cells/punch, n = 43. Multivariate analyses showing Hazard Ratios and p-value for all recurrent cancer biopsies (n = 42 less than 44 due to missing value) conferred by categorized CXCR4 expression by tumor cells, age, residual disease after cytoreductive surgery, number of chemotherapy cycles and FIGO classification.
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BMC Cancer

ISSN: 1471-2407

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