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Table 4 Uni- and multivariate Hazard Cox regression analysis of RFS in primary cancer biopsiesa

From: High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy

 

Univariate

Multivariate

HR

95% CI

p-values

HR

95% CI

p-values

Age

1.00

.97 1.03

0.888

1.00

.96 1.04

0.970

high vs low pCXCR4/CXCR4 TIC ratio

0.61

.31 1.21

0.161

0.33

.13 .81

0.015

Residual disease <2cm

1.13

.56 2.28

0.724

1.30

.56 3.03

0.542

Residual disease >2cm

3.67

1.62 8.31

0.002

7.79

2.19 27.71

0.002

N of chemotherapy cycles

1.28

1.05 1.55

0.013

2.51

.79 8.03

0.120

FIGO IIIA

0.34

.02 5.72

0.455

   

FIGO IIIB

0.93

.11 8.04

0.944

   

FIGO IIIC

1.21

.16 9.03

0.851

0.63

.17 2.29

0.480

FIGO IV

1.48

.18 11.94

0.712

1.07

.24 4.78

0.928

  1. a Cut-off = 0.1875, n = 36. Multivariate analyses showing Hazard Ratios and p-value for all primary cancer biopsies (n = 35 less than 36 due to missing value) conferred by categorized pCXCR4/CXCR4 TIC ratio in primary cancer biopsies, age, residual disease after cytoreductive surgery, number of chemotherapy cycles and FIGO classification.