High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy

Table 3 Patients’ characteristics according to CXCR4 positive tumor expression in recurrent cancer biopsies^a

	CXCR4 high	CXCR4 low	p-value
	n = 22 (100%)	n = 21 (100%)	p-value
Age (median, range)	58.5 (34-77)	57 (41-76)	0.458
FIGO stage
II	1 (4.5)	0 (0)
IIIA	1 (4.5)	0 (0)
IIIB	2 (9.1)	3 (14.3)	0.715
IIIC	13 (59.1)	15 (71.4)
IV	5 (22.7)	3 (14.3)
Residual disease
None	10 (45.5)	5 (23.8)
<2cm	8 (36.4)	7 (33.3)	0.266
>2cm	4 (18.2)	8 (38.1)
Numbers of chemotherapy cycles
<6	7 (31.8)	0 (0)	0.006
6 or more	15 (68.2)	20 (95.2)
CS^b	18 (81.8)	12 (57.1)	0.078
CR^b	4 (18.2)	9 (42.9)
6-month recurrent free survival % (95%CI)^c	0.68 (0.45-0.83)	0.48 (0.26-0.67)	0.018
3-year overall survival % (95%CI)^c	0.50 (0.23-0.72)	0.50 (0.25-0.71)	0.207

^aCut-off = 84 cells/punch, n = 43. Percentages may not add to 100% due to missing values of defined variables, missing clinicopathological information was assumed to be missing at random. Variables are indicated as absolute numbers, %, median or range. Age, RFS and OS were evaluated using the Kaplan-Meier method. FIGO stage, residual disease, numbers of chemotherapy cycles and chemoresistance were analyzed using the Chi-Square or the Fisher’s Exact test.
^bCS chemosensitive, CR chemoresistant
^cRFS recurrence-free survival, OS overall survival

ISSN: 1471-2407