High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy

Table 2 Patients' characteristics according to pCXCR4/CXCR4 TIC ratio in primary biopsies in the overall cohort^a

	pCXCR4/CXCR4^high	pCXCR4/CXCR4^low	p-value
	n=18 (100%)	n=18 (100%)	p-value
Age (median, range)	61.5 (47-73)	58 (34-69)	0.350
FIGO stage
IIIB	4 (22.2)	0 (0)
IIIC	11 (61.1)	15 (83.3)	0.149
IV	3 (16.7)	3 (16.7)
Residual disease
None	6 (33.3)	5 (27.8)
<2cm	5 (27.8)	9 (50.0)	0.277
>2cm	7 (38.9)	3 (16.7)
Numbers of chemotherapy cycles
<6	2 (11.1)	3 (16.7)	0.581
6 or more	16 (88.9)	14 (77.8)
6-month recurrent free survival % (95%CI)^b	0.73 (0.40-0.91)	0.47 (0.22-0.70)	0.128
3-year overall survival % (95%CI)^b	0.30 (0.07-0.58)	0.36 (0.13-0.59)	0.619

^a Cut-off = 0.1875, n = 36. Percentages may not add to 100% due to missing values of defined variables, missing clinicopathological information was assumed to be missing at random. Variables are indicated as absolute numbers, %, median or range. Age, RFS and OS were evaluated using the Kaplan-Meier method. FIGO stage, residual disease and numbers of chemotherapy cycles were analyzed using the Chi-Square or the Fisher’s Exact test.
^bRFS recurrence-free survival, OS overall survival

ISSN: 1471-2407