Fig. 2

Box plots showing BIRC5 expression in (A) 16 different TCGA cancer types, (B) breast cancer compared to corresponding normal tissue. BIRC5 expression is significantly higher in all of the analyzed cancer types than normal tissue. C Affymetrix HG-U133A RNA microarray dataset with 21 cancer types, and (D) Affymetrix HG-U133 Plus 2 RNA microarray dataset comprised of 25 cancer types. BIRC5 expression is significantly higher in the majority of the analyzed cancer types than normal tissue. The Wilcoxon test was used to calculate statistically significant (Benjamini-Hochberg adjusted p-values) differences in BIRC5 expression between cancer and normal tissue. ns = not significant (P > 0.05); *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001