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Fig. 1 | BMC Cancer

Fig. 1

From: Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells

Fig. 1

mRNA levels of RAB3B. a and b, M-A plots generated from RNA-sequence analysis. For each gene, the log2(average expression) in the two samples (A, x axis) against the log2(fold change) between the samples (M, y axis) is plotted. a, Magenta dots represent significant differentially expressed genes (DEGs) in SK-HEP-1 cells. Green dots indicate sphere-specific DEGs that are not significantly changed in the experiment using non-sphere forming HuH-7 cells. b, Magenta dots represent significant DEGs in primary HCCs with/without recurrence. Green dots also represent DEGs significantly changed in HCCs compared with non-tumorous liver tissue samples. Orange diamonds are overlapping DEGs. The mRNA levels of RAB3B in cell lines (c) and clinical specimens (d) were measured using qRT-PCR and are represented as the ratio of the expression with respect to that in SK-HEP-1 cells or non-tumorous liver tissues. Recurrence-free (n = 5) and recurrence (n = 5) cases consisting of a pair of HCC and adjacent non-cancerous liver samples were used. *P < 0.05 with Tukey–Kramer multiple comparison test. **, P < 0.05 with pairwise t-test

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