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Table 5 Correlations of quantitatively high TILs with clinicopathological parameters in stage IIIC/IVB endometrioid-type endometrial carcinoma (n = 47)

From: Intraepithelial lymphocytes are indicators of better prognosis in surgically resected endometrioid-type endometrial carcinomas at early and advanced stages

Parameter

Total

Number of patients (%)

Quantitatively high TILs

CD3+

P

CD8+

P

CD3+

P

CD8+

P

E-TILs

E-TILs

S-TILs

S-TILs

Age

  ≤ 50

8

2

(25)

0.25

1

(13)

0.40

3

(38)

0.23

2

(25)

1.00

  > 50

39

20

(51)

14

(36)

25

(64)

10

(26)

Stage

 IIIC

37

18

(49)

0.72

11

(30)

0.70

23

(62)

0.49

10

(27)

1.00

 IVB

10

4

(40)

4

(40)

5

(50)

2

(20)

Histological grade

 G1

12

7

(58)

0.54

6

(50)

0.075

8

(67)

0.83

3

(25)

0.99

 G2

16

6

(38)

2

(13)

9

(56)

4

(25)

 G3

19

9

(47)

7

(37)

11

(58)

5

(26)

Lymphovascular invasion

 Positive

41

16

(39)

0.0069

10

(24)

0.0094

23

(56)

0.37

10

(24)

0.63

 Negative

6

6

(100)

5

(83)

5

(83)

2

(33)

Lymph node metastasis

 Positive

42

20

(48)

1.00

13

(31)

1.00

25

(60)

1.00

11

(26)

1.00

 Negative

5

2

(40)

2

(40)

3

(69)

1

(20)

MMR protein

 Deficient

18

9

(50)

0.77

7

(39)

0.52

13

(72)

0.22

5

(28)

1.00

 Proficient

29

13

(45)

8

(28)

15

(52)

7

(24)

Total

47

22

  

15

  

28

  

12

  
  1. P values were calculated by chi-squared test or Fisher exact test
  2. E-TILs Epithelial tumor-infiltrating lymphocytes, MMR Mismatch repair, S-TILs Stromal tumor-infiltrating lymphocytes
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BMC Cancer

ISSN: 1471-2407

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