BMC Cancer

Table 4 Correlations of semiquantitative high/intermediate TILs/“TIL score” with clinicopathological parameters in stage IIIC/IVB endometrioid-type endometrial carcinoma (n = 47)

From: Intraepithelial lymphocytes are indicators of better prognosis in surgically resected endometrioid-type endometrial carcinomas at early and advanced stages

Parameter	Total	Number of cases (%)
		High/Intermediate
		CD3⁺		P	CD8⁺		P	CD3⁺		P	CD8⁺		P	“TIL score”		P
		E-TILs		P	E-TILs		P	S-TILs		P	S-TILs		P	(4 to 8)		P
Age
≤ 50	8	3	(28)	0.46	3	(28)	0.70	3	(28)	0.43	3	(28)	1.00	2	(25)	0.69
> 50	39	21	(54)	0.46	20	(51)	0.70	23	(59)	0.43	17	(44)	1.00	14	(36)	0.69
Stage
IIIC	37	20	(53)	0.49	21	(57)	0.072	21	(57)	0.73	18	(49)	0.15	14	(38)	0.45
IVB	10	4	(40)	0.49	2	(20)	0.072	5	(50)	0.73	2	(20)	0.15	2	(20)	0.45
Histological grade
G1	12	5	(42)	0.67	5	(42)	0.83	7	(58)	0.94	4	(33)	0.38	2	(17)	0.28
G2	16	8	(50)		8	(50)		9	(56)		9	(56)		7	(44)
G3	19	11	(53)		10	(53)		10	(53)		7	(37)		7	(37)
Lymphovascular invasion
Positive	41	20	(49)	0.66	19	(46)	0.41	21	(51)	0.20	16	(39)	0.37	13	(32)	0.39
Negative	6	4	(67)	0.66	4	(67)	0.41	5	(83)	0.20	4	(67)	0.37	3	(50)	0.39
Lymph node metastasis
Positive	42	22	(52)	0.66	21	(50)	1.00	24	(57)	0.64	19	(45)	0.37	14	(33)	1.00
Negative	5	2	(40)	0.66	2	(40)	1.00	2	(40)	0.64	1	(20)	0.37	2	(40)	1.00
MMR protein
Deficient	18	9	(50)	1.00	8	(44)	0.76	10	(56)	1.00	8	(44)	1.00	5	(28)	0.54
Proficient	29	15	(52)	1.00	15	(52)	0.76	16	(55)	1.00	12	(41)	1.00	11	(38)	0.54
Total	47	24			23			26			20			16

P values were calculated by chi-squared test or Fisher exact test
E-TILs Epithelial tumor-infiltrating lymphocytes, MMR Mismatch repair, S-TILs Stromal tumor-infiltrating lymphocytes

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