Fig. 4

Survival analyses using semiquantitative TILs and TAMs in 47 stage IIIC/IVB endometrioid-type endometrial carcinoma. A Forest plot of Cox univariate analyses. B Forest plot of multivariate analysis. Multivariate analysis incorporates univariably significant parameters and “TIL score” as representative of semiquantitative TILs indicators. Vertical line: risk in logarithm. C–G Recurrence-free survival/progression-free survival curves. Curves stratified by semiquantitative (C) CD3⁺ E-TILs, (D) CD8⁺ E-TILs, (E) CD3⁺ stromal TILs (S-TILs), (F) CD8⁺ S-TILs, and (G) “TIL score”. There were significant differences in the curves between the high/intermediate and low CD3⁺ E-TILs, CD8⁺ E-TILs and CD8⁺ S-TILs groups (P = 0.0089, 0.0043 and 0.035, respectively) and between high (score 4–8) and low (0–3) “TIL score” groups (P = 0.024). LVI, lymphovascular invasion; MMR, mismatch repair