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Table 3 The association of 40-year-old early-onset breast cancer with sociodemographic characteristics and correlated with menarcheal age

From: Association of early-onset breast cancer with body mass index, menarche, and menopause in Taiwan

  The risk of 40-year-old early-onset breast cancer The risk of early-onset breast cancer by per 1 year younger at menarche The risk of 40-year-old early-onset breast cancer The risk of early-onset breast cancer by per 1 year younger at menarche
Characteristics cOR (95% CI)a P-values cOR (95% CI)a P-values aOR (95% CI)b P-values aOR (95% CI)b P-values
BMI (kg/m2)
  BMI < 24 2.52 (1.64–3.88)  < 0.001 1.49 (1.24–1.78)  < 0.001 1.76 (1.09–2.84) 0.020 1.26 (1.03–1.55) 0.028
  BMI ≥ 24 1   1.41 (1.09–1.83) 0.008 1   1.23 (0.92–1.63) 0.162
Education
  < college 1   1.20 (0.96–1.50) 0.110 1   1.15 (0.89–1.47) 0.282
  ≥ college 4.35 (2.92–6.50)  < 0.001 1.36 (1.12–1.65) 0.002 2.54 (1.62–3.98)  < 0.001 1.30 (1.04–1.62) 0.022
Marriage
  Unmarried/Divorce/Widowed 2.48 (1.66–3.72)  < 0.001 1.28 (0.98–1.67) 0.066 0.88 (0.44–1.77) 0.726 1.05 (0.78–1.40) 0.749
  Married 1   1.49 (1.25–1.77)  < 0.001 1   1.32 (1.08–1.61) 0.008
Physical activity
  None 1.50 (1.03–2.18) 0.036 1.45 (1.18–1.78)  < 0.001 1.40 (0.90–2.17) 0.138 1.27 (0.99–1.62) 0.058
  Yes 1   1.37 (1.13–1.67) 0.001 1   1.20 (0.96–1.51) 0.113
Menopausal status
  Premenopause 7.54 (5.02–11.32)  < 0.001 1.09 (0.87–1.37) 0.436 4.59 (2.94–7.16)  < 0.001 1.12 (0.86–1.46) 0.397
  Peri-/Postmenopause 1   1.39 (1.13–1.71) 0.002 1   1.35 (1.09–1.69) 0.007
BMI < 24
  Premenopause 9.25 (5.63–15.18)  < 0.001 1.20 (0.91–1.59) 0.205 6.47 (3.76–11.13)  < 0.001 1.12 (0.83–1.51) 0.446
  Peri-/Postmenopause 1   1.45 (1.09–1.92) 0.010 1   1.42 (1.05–1.91) 0.022
BMI ≥ 24
  Premenopause 3.51 (1.59–7.75) 0.002 1.22 (0.74–2.02) 0.435 2.18 (0.93–5.12) 0.073 1.28 (0.67–2.42) 0.457
  Peri-/Postmenopause 1   1.34 (0.98–1.84) 0.067 1   1.27 (0.91–1.78) 0.161
Parity
  Nulliparous 4.71 (3.09–7.18)  < 0.001 1.18 (0.91–1.53) 0.220 3.10 (1.53–6.29) 0.002 1.01 (0.75–1.36) 0.964
  Parous 1   1.52 (1.27–1.81)  < 0.001 1   1.33 (1.09–1.62) 0.005
Number of births
  One 2.48 (1.42–4.33) 0.001 1.73 (1.14–2.63) 0.011 1.60 (0.85–3.01) 0.149 1.59 (0.99–2.53) 0.054
  More than one 1   1.46 (1.20–1.78)  < 0.001 1   1.28 (1.02–1.60) 0.033
Age at first birth
  < 27 years 1   1.33 (0.99–1.79) 0.060 1   1.19 (0.85–1.67) 0.318
  ≥ 27 years 2.83 (1.69–4.72)  < 0.001 1.52 (1.21–1.91)  < 0.001 1.28 (0.70–2.33) 0.421 1.35 (1.04–1.73) 0.022
Lactation history
  Never 1   1.29 (0.91–1.83) 0.148 1   1.21 (0.83–1.76) 0.333
  Ever 2.21 (1.31–3.74) 0.003 1.62 (1.32–1.99)  < 0.001 1.87 (1.06–3.28) 0.030 1.38 (1.09–1.76) 0.008
Fried food
  1 ~ 2 times a week 1   1.32 (1.14–1.53)  < 0.001 1   1.19 (1.00–1.41) 0.055
  3 ~ 6 times a week 3.94 (2.08–7.47)  < 0.001 1.72 (1.10–2.70) 0.019 1.97 (0.91–4.26) 0.085 1.20 (0.47–3.04) 0.707
Benign breast disease
  Never 1   1.37 (1.17–1.61)  < 0.001 1   1.17 (0.96–1.42) 0.117
  Ever 1.14 (0.74–1.76) 0.559 1.53 (1.16–2.03) 0.003 1.11 (0.68–1.83) 0.670 1.44 (1.03–2.00) 0.031
Family history of BC
  None 1   1.36 (1.16–1.60)  < 0.001 1   1.20 (0.99–1.46) 0.062
  Yes 1.48 (0.96–2.29) 0.074 1.56 (1.15–2.11) 0.004 1.43 (0.87–2.36) 0.163 1.32 (0.92–1.91) 0.133
  1. BMI body mass index, OR odds ratio, CI confidence interval
  2. aCrude odds ratio (cOR) was calculated by multivariable logistic regression
  3. bAdjusted for BMI, education, marriage, physical activity, menopausal status, and parity, shown as aOR (95% CI)