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Table 2 The clinical characteristics between early-onset and late-onset breast cancer participants

From: Association of early-onset breast cancer with body mass index, menarche, and menopause in Taiwan

Characteristics, n (%) Early-onset
(≤ 40 years old)
(n = 131)
Late-onset
(> 40 years old)
(n = 644)
P-valuesa P-values after Bonferroni correction
Breast density     < 0.001 0.0048
  Fatty + Mildly dense 10 (7.9) 99 (16.5)   
  Moderately 84 (66.7) 426 (71.0)   
  Extremely 32 (25.4) 75 (12.5)   
Molecular subtype    0.322 1.000
  Luminal A 78 (65.5) 379 (62.0)   
  Luminal B 22 (18.5) 107 (17.5)   
  HER2-enriched 7 (5.9) 71 (11.6)   
  Triple negative 12 (10.1) 54 (8.8)   
TNM stage    0.822 1.000
  0/I/II 108 (84.4) 529 (83.6)   
  III/IV 20 (15.6) 104 (16.4)   
Grade    0.761 1.000
  Well differentiated 16 (13.7) 85 (13.8)   
  Moderately differentiated 65 (55.6) 321 (52.1)   
  Poorly differentiated 36 (30.8) 210 (34.1)   
Tumor size    0.251 1.000
  ≤ 2 cm 68 (54.4) 371 (59.9)   
  > 2 cm 57 (45.6) 248 (40.1)   
Invasive    0.055 1.000
  None 9 (8.9) 91 (16.4)   
  Yes 92 (91.1) 465 (83.6)   
ER status    0.272 1.000
  ER-negative 22 (17.5) 138 (21.8)   
  ER-positive 104 (82.5) 494 (78.2)   
PR status    0.270 1.000
  PR-negative 37 (29.8) 220 (35.0)   
  PR-positive 87 (70.2) 409 (65.0)   
HER2 status    0.292 1.000
  HER2-negative 90 (75.6) 433 (70.9)   
  HER2-positive 29 (24.4) 178 (29.1)   
  1. TNM stage TNM classification of malignant tumors, ER Estrogen receptor, PR Progesterone receptor, HER2 Human epidermal growth factor receptor 2. aP-values were calculated for categorical variables by Chi-square test