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Fig. 6 | BMC Cancer

Fig. 6

From: Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells

Fig. 6

Proposed drug target genes. Prioritized nodes for Huh7 and Mahlavu was ranked by betweenness centrality values of randomized networks for each inhibitor treatment (A). Expressions of the genes in the cell lines. Prioritized treatments were pointed for corresponding drug treatment target (B). Relative expression profile of Mahlavu (C) and Huh7 (D) cells for AOX1 and AGER genes determined by qRT-PCR. Expression values were normalized with RPL19. Experiment was performed as triplicates and for statistical analysis, unpaired t-test with Welch correction was performed. *p < 0.05; **p < 0.01. ALPHA; PI3Ki-α inhibitor, HBETA; PI3Ki-β inhibitor, SALPHA; PI3Ki-α inhibitor and SOR, SBETA; PI3Ki-β inhibitor and SOR, SOR; Sorafenib treated cells

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