Fig. 4

Gene Expression Patterns. Heatmaps of gene expressions illustrated as dendrograms separately for Huh7 and Mahlavu cells lines. We removed single PI3K-β inhibitor treatments for both cell lines considering its ineffectiveness. Sample sets for Huh7 and Mahlavu were separately joined, and united sets included 11,033 and 11,615 genes in total before filtration. Gene enrichment analysis was performed using BiNGO (FDR ≤ 0.05) and significant gene ontologies were selected according to the context. Hence, dendrogram analysis were performed on 581 genes for Huh7 and 583 genes for Mahlavu cells. For more detailed analysis and to view interactive dendrogram please see CanSyL github repository. Clusters were generated by heatmaply and colored; 8 for Huh7 and 6 for Mahlavu. Clusters not showing any significant enrichment were excluded. Up- and downregulated gene expression levels are colored as red and blue respectively, the intensity of the color indicates how strong the logFC value is. ALPHA; PIK-75, SALPHA; PIK-75 and Sorafenib, SBETA; TGX-221 and Sorafenib, SOR; Sorafenib treatments