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Fig. 1 | BMC Cancer

Fig. 1

From: Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells

Fig. 1

Characterization of HCC cells in the presence of small molecules inhibitors. Real time cell growth analysis of Huh7 and Mahlavu cells with increasing concentrations (40 μM, 20 μM, 10 μM, 5 μM, 2.5 μM) of Sorafenib, PI3K inhibitor LY294002, PI3Ki-β inhibitor (TGX-22) and PI3Ki-α (1 μM, 0.5 μM, 0.25 μM, 0.125 μM, 0.0625 μM) PI3Ki-α (PIK-75) along with DMSO vehicle control (Control is black and increasing drug concentrations is given in grey level, highest concentration is being the darkest) (A). Cell cycle analysis with flow cytometry. Sub-G1 population represents apoptotic cells (B). Wound healing assay for 24 and 48 h for cell migration. (C). 10 μM of Sorafenib, LY294002 and PI3Ki-β (TGX-221) and 0.1 μM of PI3Ki-α (PIK-75) were used for cell cycle and migration assays

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