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Table 4 OSNA accuracy compared with histopathological examination in included tumours

From: Application of One-Step Nucleic Acid Amplification (OSNA) in different cancer entities and usefulness in prostate cancer: a systematic review

Group Author H&E positive H&E negative Sensitivity Specificity Concordance
OSNA negative OSNA positive OSNA negative OSNA positive
1) Tsujimoto et al. [15] 0.6 (2) 13.2 (43) 85 (276) 1.2 (4) 95.6 98.6 98.2 (319/325)
Feldman et al. [28] 3 (31) 10.2 (107) 83.1 (868) 3.6 (38) 77.5 95.8 93.4 (975/1044)
Le Frère-Belda et al. [29] 2.4 (12) 10.1 (51) 82.1 (413) 5.4 (27) 80.9 93.9 92.2 (464/503)
Vegué et al. [30] 0 (0) 1.1 (6) 92.1 (522) 6.9 (39) 100 93 93.1 (528/567)
Wang et al. [31] 2.6 (31) 13.4 (159) 78 (927) 6 (71) 83.7 92.9 91.4 (1086/1188)
Pathmanathan et al. [32] 1.8 (3) 14.7 (25) 80.6 (137) 3 (5) 89.3 96.5 95.3 (162/170)
Banerjee et al. [33] 0.7 (2) 14.6 (39) 81 (217) 3.7 (10) 95.1 95.6 95.5 (256/268)
Li et al. [34] 2 (6) 9.6 (30) 85.5 (266) 2.9 (9) 83.3 96.7 95.2 (296/311)
2) Croner et al. [35] 1.6 (3) 20.1 (37) 75.5 (139) 2.7 (5) 92.5 96.5 95.7 (176/184)
Yamamoto et al. [36] 1 (4) 20.5 (79) 76.6 (295) 1.8 (7) 95.2 97.7 97.1 (374/385)
Guller et al. [37] 0.6 (2) 16.3 (51) 79.6 (249) 3.5 (11) 96.2 95.7 95.8 (300/313)
Yamamoto et al. [38] 1 (20) 6.5 (125) 89.2 (1717) 3.3 (63) 86.2 96.5 95.7 (1842/1925)
Yaguchi et al. [39] 3.1 (5) 24.7 (40) 69.8 (113) 2.5 (4) 88.9 96.6 94.4 (153/162)
Kumagai et al. [40] 2.3 (9) 11.4 (45) 82.7 (326) 3.6 (14) 83.3 95.9 94.2 (371/394)
Shimada et al. [41] 1.8 (8) 3.2 (14) 93.9 (412) 1.1 (5) 63.6 98.8 97 (426/439)
3) Okamoto et al. [42] 2.3 (3) 2.3 (3) 93.8 (122) 1.5 (2) 50 98.4 96.2 (125/130)
Nagai et al. [43] 2.2(3) 10.2 (14) 86.9 (119) 0.7 (1) 82.4 99.2 97.1 (133/137)
Fanfani et al. [44] 0.9 (1) 7.2 (8) 86.4 (95) 5.4 (6) 88.9 94.1 93.6 (103/110)
Kost’un et al. [45] 0.7 (1) 7.4 (10) 78.5 (106) 13.3 (18) 90.9 85.5 85.9 (116/135)
4) Inoue et al. [46] 0.6 (1) 11.5 (19) 87.3 (144) 0.6 (1) 95 99.3 98.8 (163/165)
Nakagawa et al. [47] 2.9 (12) 11.5 (47) 81.2 (333) 4.4 (18) 79.7 94.5 92.7 (380/410)
Escalante-Pérez et al. [48] 0.1 (1) 4.8 (34) 91.3 (644) 3.7 (26) 97.1 96.1 96.2 (678/705)
5) Goda et al. [49] 2.6 (8) 17 (53) 77.2 (241) 3.2 (10) 86.9 96 94.2 (294/312)
Sofía del Carmen et al. [50] 5.2 (14) 28.1 (75) 60 (160) 6.7 (18) 84.2 89.9 88 (235/267)
6) Engels et al. [24] 2.2 (12) 14.2 (76) 80.5 (452) 3.4 (18) 91.4 100 98.8 (528/534)
  1. Figures are expressed as percentages and (number of cases) in parentheses
  2. H&E Hematoxylin and eosin, No Number of, OSNA One-step nucleic acid amplification