Fig. 2

Restorative upregulation of steroid biosynthesis and terpenoid backbone biosynthesis pathways associate with fluvastatin resistance in an in vitro model of acquired resistance. A Heatmap showing the steroid biosynthesis and terpenoid backbone biosynthesis among the top 3 significantly upregulated pathways (FDR < 5%) and B & C the genes that map in these pathways in the fluvastatin resistant MCF10.AT-R cells. (B & C, black bar) The row-side color bars represent genes that are shared between steroid biosynthesis pathway and inherent gene signature (IRS) and between terpenoid backbone biosynthesis pathways and IRS. (B & C, gray bar) genes that were found to be upregulated exclusively in the MCF10.AT-R cells (SEAR). (D) Lists of genes that are either shared with IRS or the ones that were found to be upregulated exclusively in the MCF10.AT-R cells (SEAR) representing the unique gene signature of acquired resistance to fluvastatin