Fig. 1
From: Gene signature associated with resistance to fluvastatin chemoprevention for breast cancer
Inherent resistance to fluvastatin correlates with high baseline expression of cholesterol biosynthesis genes in a model of breast cancer progression. A Heatmap showing upregulation of a 17 gene panel that was derived by taking log 2 transformed folds of the genes in this supervised heatmap. The X-axis shows breast cancer progression and the Y-axis shows the gene names that were sorted by the averaged folds (top to bottom: smaller to larger folds). B Colony formation assay (CFA) showing the crystal violet stained colonies in the fluvastatin sensitive MCF10.AT1 and fluvastatin resistant MCF10.DCIS cells with or without fluvastatin treatment. *p < 0.05