Patient’s parameters | Statue of TET2 mutation | P | |
---|---|---|---|
Germline mutation(n = 33) | Somatic mutation(n = 67) | ||
Age(Y)median(range) | 48(16–82) | 66(24–89) | 0.0058 |
Male (%) | 18(54.5%) | 44(65.7%) | 0.381 |
VAF (%) median(range) | 50.6(40.5–55) | 44.1(6.14–95.9) | < 0.0001 |
Cytogenetics (%) | 0.421 | ||
Normal or -Y alone | 18(54.5%) | 47(70.1%) | |
Complex | 2(6.1%) | 4(6%) | |
Others | 6(18.2%) | 9(13.4%) | |
Unknown | 7(21.2%) | 7(10.4%) | |
Diagnosis (n) | 0.0004 | ||
MDS | 13(39.4%) | 18(26.9%) | |
AML | 3(9.1%) | 26(38.8%) | |
AA | 4(12.1%) | 1(1.5%) | |
MDS/MPN | 0(0%) | 10(13.4%) | |
Others | 13(39.4%) | 12(19.4%) | |
Peripheral blood median(range) | |||
Haemoglobin (g/L) | 74(27–160) | 81(37–135) | 0.2613 |
WBC (×109/L) | 4.4(0.23–33.38) | 7.33(0.97–237.29) | 0.0046 |
Platelet (× 109/L) | 57.5(3–611) | 59(6–1085) | 0.533 |
Absolute Neutrophils (×109/L) | 1.58(0–25.37) | 1.89(0.06–92.99) | 0.5216 |
Absolute Lymphocyte (×109/L) | 1.33(0.2–3) | 1.63(0.27–12.52) | 0.0848 |
Absolute Monocyte (×109/L) | 0.24(0–0.83) | 0.25(0–10.64) | 0.4235 |
Bone marrow (%) median(range) | |||
Myeloblast | 2(0.5–15.5) | 7.25(0.5–86) | 0.0028 |
Basophilic Erythroblast | 1.5(0.5–5) | 1.5(0.5–9) | 0.9502 |
Polychromatophilic erythroblast | 8.5(1.5–25.5) | 6.5(0.5–36) | 0.2890 |
Acidophilic Erythroblast | 16.5(2.5–51.5) | 10.75(0.5–48.5) | 0.1005 |
Mature Monocyte | 1.5(0.5–21) | 3(0.5–12) | 0.0799 |
Mature Lymphocyte | 16(5–70) | 6.5(0.5–42.5) | < 0.0001 |
Total Eosinophils | 2(0.5–10.5) | 1(0.5–9) | 0.0247 |
ESG | 1.5(0.5–5) | 0.5(0.5–3) | 0.0083 |
Mutate gene(n) | |||
CEBPA (+/−) | 1/32(3.0%) | 11/56(16.4%) | 0.0973 |
FLT3 (+/−) | 1/32(3.0%) | 6/61(9.0%) | 0.4202 |
NPM1 (+/−) | 0/33(0.00%) | 11/56(16.4%) | 0.0144 |
RUNX1 (+/−) | 2/31(6.1%) | 10/57(14.9%) | 0.3273 |
ASXL1 (+/−) | 1/32(3.0%) | 16/51(23.9%) | 0.0096 |
TP53(+/−) | 6/26(18.18%) | 6/61(9.0%) | 0.2027 |
DNMT3A (+/−) | 1/32(3.0%) | 12/55(17.9%) | 0.0551 |
ZRSR2 (+/−) | 6/28(18.18%) | 11/56(16.42%) | > 0.999 |
SF3B1 (+/−) | 1/32(3.0%) | 8/59(11.9%) | 0.2646 |
SRSF2 (+/−) | 0/33(0.0%) | 6/61(9.0%) | 0.1739 |