Table 4 Univariate and multivariate Cox regression analysis for 1-year RFS of HCC patients baseline

Gender(male/female)

71(87.7%)/10(12.3%)

227(81.4%)/52(18.6%)

0.170

0.629(0.325-1.220)

0.025

0.455(0.228-0.906)

Diabetes(yes/no)

17(21.0%)/64(79.0%)

30(10.8%)/249(89.2%)

0.016

1.930(1.130-3.297)

0.005

2.210(1.264-3.866)

ALT, U/L (≤50/>50)

66(81.5%)/15(18.5%)

221(79.2%)/58(20.8%)

0.569

0.850(0.485-1.489)

0.001

0.334(0.175-0.635)

PT, seconds (≤13/>13)

70(86.4%)/11(13.6%)

233(83.5%)/46(16.5%)

0.633

0.856(0.453-1.617)

–

–

INR(≤1/>1)

20(24.7%)/61(75.3%)

65(23.3%)/214(76.7%)

0.868

0.958(0.578-1.588)

–

–

AFP, ng/mL

–

–

–

–

≤20

21(25.9%)

146(52.3%)

–

–

–

–

20-400

21(25.9%)

75(26.9%)

0.044

1.860(1.016-3.406)

0.040

1.923(1.032-3.583)

>400

39(48.2%)

59(20.8%)

<0.001

3.520(2.07-5.983)

<0.001

2.805(1.602-4.911)

PNI

46.4(26.6,65.8)

49.5(26.5,73.3)

0.004

0.953(0.923-0.985)

–

–

APRI

0.30(0.07,4.58)

0.21(0.04,2.16)

<0.001

2.072(1.421-3.020)

<0.001

2.86(1.764-4.637)

ANRI

13.33(1.51,209.06)

9.8(1.72,63.53)

<0.001

1.016(1.007-1.025)

–

–

SIRI

0.92(0.21,75.43)

0.83(0.21,51.33)

0.039

1.027(1.001-1.052)

0.021

1.032(1.005-1.060)

MVI(yes/no)

62(76.5%)/19(13.5%)

118(42.3%)/161(57.7%)

<0.001

3.572(2.136-5.974)

<0.001

2.889(1.662-5.021)

Cirrhosis(yes/no)

42(5.9%)/39(48.1%)

131(47.0%)/148(53.0%)

0.265

1.282(0.829-1.983)

–

–

Number of tumours(solitary/multiple)

25(30.9%)/56(69.1%)

45(16.1%)/234(83.9%)

0.003

2.052(1.280-3.289)

0.054

1.621(0.991-2.652)

Tumour diameter,cm

6.49±3.53

4.55±2.78

<0.001

1.154(1.094-1.217)

0.002

1.098(1.034-1.165)

PVTT(yes/no)

19(23.5%)/62(76.5%)

11(3.9%)/268(96.1%)

<0.001

4.189(2.504-7.008)

0.001

2.503(1.431-4.378)