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Fig. 6 | BMC Cancer

Fig. 6

From: An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy

Fig. 6

Validation analysis using the Marisa 585 CRC tumor dataset. (a) Scatter plots of the 18-gene MEK activation vs. the 13-gene MEKi bypass (BP) and the 13-gene MEKi BP vs. SRC activation signature scores in Marisa 585 CRCs. Higher (> 0 median) vs lower (< 0, median) scores are indicated by red vs blue colors. (b) Spearman correlation heatmap of the signature scores and CMS1*, CMS2*, CMS3* and CMS4* scores (measuring a propensity of a tumor to fall into CMS1, CMS2, CMS2 and CMS4 classes, respectively) in Marisa 585 CRC tumors. (c) Scatter plots of Hu-Lgr5-ISC, Hu-EphB2-ISC, Hu-Late TA, and Hu-Proliferation vs EMT signature scores, respectively (n = 585 CRCs). The quartile scores (Q1-Q4) of SRC activation signature are indicated by different colors (Q1, blue; Q2, green; Q3, yellow; Q4 red). (d) Comparison of the signature scores among the CMS1-4 subtypes (n = 498). Bars represent Mean with standard errors (SEM). P values are for two-tailed Mann Whitney test

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