Fig. 2

The 13-gene MEKi “bypass” resistance score–-but not the 18-gene MEK pathway activation signature score–-was strongly correlated with SRC activation and 5-gene dasatinib sensitivity (Dasa-S) signature scores in 2250 human CRCs. (a-f) Spearman correlation analyses of the 18-gene MEK activation, 13-gene MEKi bypass, SRC activation and 5-gene Dasa-S signature scores in 2250 CRCs. Higher (> 0 median) vs lower (< 0, median) scores are indicated by red vs blue colors. Comparison of SRC activation scores in 2249 primary vs metastatic tumors (g) and in 1427 Stage I vs II vs III vs IV primary tumors (h). Bars represent Median with interquartile range. P values are for two-tailed Mann Whitney test (right panels). (i) The Kaplan–Meier (KM) survival analysis of SRC activation quartile scores in 2135 CRCs which had corresponding overall survival (OS) data. SRC activation/dependency is a prominent feature of tumors expressing the 13-gene bypass-resistance pathway activities. The SRC activation signature score was significantly associated with metastasis and primary tumor stage I-IV progression and poor overall survival