Fig. 1

Analysis of an 18-gene MEK pathway activation signature score versus a 13-gene MEKi “bypass” resistance signature score in 468 human CRCs. (a,b) mutant vs WT RAS/BRAF; (c,d) MSI vs MSS tumors; (e,f) primary vs metastatic tumors. Spearman correlation of 18-gene vs 13-gene scores is shown (left panels). (Right panels) bars represent Median with interquartile range and P values are for two-tailed Mann Whitney test. The 18 gene MEK activation and the 13 gene MEKi bypass signature scores show a poor correlation indicating that these two scores measure independent properties