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Table 1 Characteristics of patients receiving a first-line treatment for advanced NSCLC in the pre– and post–I-O periods

From: Trends in treatment patterns and survival outcomes in advanced non-small cell lung cancer: a Canadian population-based real-world analysis

  PreI-O
(1 January 2010–31 March 2016)
PostI-O
(1 April 2016–30 June 2019)
All (N = 1501)a NSQ (n = 1026) SQ (n = 225) All (N = 743)b NSQ (n = 553) SQ (n = 129)
Age,c years
Median
Q1–Q3
Range
65
58–72
26–91
64
56–72
26–91
68
61–72
39–85
68
60–74
27–96
66
59–74
27–96
69
63–73
43–86
Female, n (%) 763 (50.8) 555 (54.1) 85 (37.8) 388 (52.2) 314 (56.8) 42 (32.6)
Initial TNM stage, n (%)
I–IIIAd 159 (10.6) 89 (8.7) 46 (20.4) 129 (17.4) 85 (15.4) 38 (29.5)
IIIB 186 (12.4) 102 (9.9) 53 (23.6) 83 (11.2) 46 (8.3) 31 (24.0)
IV 1156 (77.0) 835 (81.4) 126 (56.0) 531 (71.5) 422 (76.3) 60 (46.5)
Location of metastases, n (%)
Visceral, excl. adrenal/liver 390 (26.0) 297 (28.9) 35 (15.6) 192 (25.8) 157 (28.4) 22 (17.1)
Bone 259 (17.3) 194 (18.9) 26 (11.6) 118 (15.9) 100 (18.1) 12 (9.3)
Liver 144 (9.6) 102 (9.9) 15 (6.7) 43 (5.8) 35 (6.3) 5 (3.9)
Brain 132 (8.8) 109 (10.6)  < 5 88 (11.8) 75 (13.6) 7 (5.4)
Lymph 114 (7.6) 76 (7.4) 17 (7.6) 58 (7.8) 43 (7.8) 9 (7.0)
Adrenal 80 (5.3) 61 (5.9) 8 (3.6) 40 (5.4) 34 (6.1)  < 5
CCI, n (%)
0 477 (31.8) 331 (32.3) 69 (30.7) 229 (30.8) 178 (32.2) 34 (26.4)
1 345 (23.0) 222 (21.6) 66 (29.3) 164 (22.1) 114 (20.6) 39 (30.2)
2 159 (10.6) 102 (9.9) 32 (14.2) 76 (10.2) 54 (9.8) 17 (13.2)
3 202 (13.5) 147 (14.3) 23 (10.2) 93 (12.5) 69 (12.5) 17 (13.2)
4 +  318 (21.2) 224 (21.8) 35 (15.6) 181 (24.4) 138 (25.0) 22 (17.1)
  1. Unless otherwise indicated, all characteristics were recorded at time of diagnosis. Data were masked when patient numbers for an individual category were greater than zero but less than 5
  2. Abbreviations: CCI Charlson Comorbidity Index; I-O immuno-oncology; NOS not otherwise specified; NSCLC non-small cell lung cancer; NSQ non-squamous; Q quartile; SQ squamous; TNM tumor, nodes, metastasis
  3. aPatients had NSQ (n = 1026), SQ (n = 225), NOS (n = 226) or Other (n = 24) histology
  4. bPatients had NSQ (n = 553), SQ (n = 129), NOS (n = 52) or Other (n = 9) histology
  5. cAge recorded at start of first-line treatment for advanced NSCLC
  6. dPatients with TNM stage I–IIIA NSCLC at diagnosis represent “progressed patients” who subsequently received systemic anticancer therapy during the study period (see Additional file 1)