Pre–I-O (1 January 2010–31 March 2016) | Post–I-O (1 April 2016–30 June 2019) | |||||
---|---|---|---|---|---|---|
All (N = 1501)a | NSQ (n = 1026) | SQ (n = 225) | All (N = 743)b | NSQ (n = 553) | SQ (n = 129) | |
Age,c years | ||||||
Median Q1–Q3 Range | 65 58–72 26–91 | 64 56–72 26–91 | 68 61–72 39–85 | 68 60–74 27–96 | 66 59–74 27–96 | 69 63–73 43–86 |
Female, n (%) | 763 (50.8) | 555 (54.1) | 85 (37.8) | 388 (52.2) | 314 (56.8) | 42 (32.6) |
Initial TNM stage, n (%) | ||||||
I–IIIAd | 159 (10.6) | 89 (8.7) | 46 (20.4) | 129 (17.4) | 85 (15.4) | 38 (29.5) |
IIIB | 186 (12.4) | 102 (9.9) | 53 (23.6) | 83 (11.2) | 46 (8.3) | 31 (24.0) |
IV | 1156 (77.0) | 835 (81.4) | 126 (56.0) | 531 (71.5) | 422 (76.3) | 60 (46.5) |
Location of metastases, n (%) | ||||||
Visceral, excl. adrenal/liver | 390 (26.0) | 297 (28.9) | 35 (15.6) | 192 (25.8) | 157 (28.4) | 22 (17.1) |
Bone | 259 (17.3) | 194 (18.9) | 26 (11.6) | 118 (15.9) | 100 (18.1) | 12 (9.3) |
Liver | 144 (9.6) | 102 (9.9) | 15 (6.7) | 43 (5.8) | 35 (6.3) | 5 (3.9) |
Brain | 132 (8.8) | 109 (10.6) | < 5 | 88 (11.8) | 75 (13.6) | 7 (5.4) |
Lymph | 114 (7.6) | 76 (7.4) | 17 (7.6) | 58 (7.8) | 43 (7.8) | 9 (7.0) |
Adrenal | 80 (5.3) | 61 (5.9) | 8 (3.6) | 40 (5.4) | 34 (6.1) | < 5 |
CCI, n (%) | ||||||
0 | 477 (31.8) | 331 (32.3) | 69 (30.7) | 229 (30.8) | 178 (32.2) | 34 (26.4) |
1 | 345 (23.0) | 222 (21.6) | 66 (29.3) | 164 (22.1) | 114 (20.6) | 39 (30.2) |
2 | 159 (10.6) | 102 (9.9) | 32 (14.2) | 76 (10.2) | 54 (9.8) | 17 (13.2) |
3 | 202 (13.5) | 147 (14.3) | 23 (10.2) | 93 (12.5) | 69 (12.5) | 17 (13.2) |
4 + | 318 (21.2) | 224 (21.8) | 35 (15.6) | 181 (24.4) | 138 (25.0) | 22 (17.1) |