Table 1 The comparison of characteristics between chart review and algorithm determined cohort
Variable | Chart-review determined | Algorithm estimated recurrence | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Entire cohort (N = 598) N(%) | Recurrence (N = 121) N(%) | P-value | High-accuracy (N = 116) N(%) | P-value^ | High-PPV (N = 99) N(%) | P-value^ | High-sensitivity (N = 144) N(%) | P-value^ | ||
Age (year) | Median (IQR) | 40 (36–53) | 40 (36–50) | 0.545 | 40 (37–53) | 0.436 | 40 (37–50) | 0.883 | 40 (36–53) | 0.405 |
Stage* | 0-I | 95 (15.9) | 9 (7.4) | < 0.0001 | 5 (4.3) | 0.423 | 6 (6.1) | 0.598 | 10 (6.9) | 0.921 |
II | 311 (52) | 41 (33.9) | 39 (33.6) | 30 (30.3) | 51 (35.4) | |||||
III | 192 (32.1) | 71 (58.7) | 72 (62.1) | 63 (63.6) | 83 (57.6) | |||||
PR | Negative | 223 (37.3) | 51 (42.1) | 0.216 | 54 (46.6) | 0.332 | 41 (41.4) | 0.89 | 63 (43.8) | 0.688 |
Positive | 375 (62.7) | 70 (57.9) | 62 (53.4) | 58 (58.6) | 81 (56.3) | |||||
ER | Negative | 159 (26.6) | 37 (30.6) | 0.266 | 40 (34.5) | 0.364 | 31 (31.3) | 0.878 | 47 (32.6) | 0.596 |
Positive | 439 (73.4) | 84 (69.4) | 76 (65.5) | 68 (68.7) | 97 (67.4) | |||||
HER2* | Negative | 437 (73.1) | 98 (81) | 0.028 | 93 (80.2) | 0.82 | 79 (79.8) | 0.761 | 112 (77.8) | 0.324 |
Positive | 161 (26.9) | 23 (19) | 23 (19.8) | 20 (20.2) | 32 (22.2) | |||||
Tumor histology | Ductal | 538 (90) | 106 (87.6) | 0.349 | 98 (84.5) | 0.595 | 83 (83.8) | 0.478 | 125 (86.8) | 0.949 |
Lobular | 27 (4.5) | 5 (4.1) | 6 (5.2) | 6 (6.1) | 6 (4.2) | |||||
Others | 33 (5.5) | 10 (8.3) | 12 (10.3) | 10 (10.1) | 13 (9.1) | |||||
Tumor grade | 1 | 45 (7.5) | 5 (4.1) | 0.284 | 6 (4.2) | 0.024 | 4 (4.0) | 0.04 | 4 (3.5) | 0.038 |
2 | 211 (35.3) | 44 (36.3) | 46 (31.9) | 30 (30.3) | 35 (30.2) | |||||
3 | 342 (57.2) | 72 (59.5) | 92 (63.9) | 65 (65.7) | 77 (66.4) | |||||
Surgery* | No surgery | 5 (0.8) | 1 (0.8) | 0.002 | 1 (0.9) | 0.370 | 1 (1) | 0.052 | 5 (3.5) | 0.135 |
BCS | 159 (26.6) | 18 (14.9) | 13 (11.2) | 7 (7.1) | 23 (16) | |||||
Mastectomy | 434 (72.6) | 102 (84.3) | 102 (87.9) | 91 (91.9) | 116 (80.6) | |||||
Chemotherapy | No | 51 (8.5) | 10 (8.3) | 0.614 | 7 (6) | 0.377 | 7 (7.1) | 0.658 | 15 (10.4) | 0.357 |
Yes | 547 (91.5) | 111 (91.7) | 109 (94) | 92 (92.9) | 129 (89.6) | |||||
Hormone therapy | No | 192 (32.1) | 43 (35.5) | 0.396 | 36 (31) | 0.397 | 32 (32.3) | 0.63 | 49 (34) | 0.762 |
Yes | 214 (35.8) | 37 (30.6) | 34 (29.3) | 29 (29.3) | 42 (29.2) | |||||
Unknown | 192 (32.1) | 41 (33.9) | 46 (39.7) | 38 (38.4) | 53 (36.8) | |||||
Radiotherapy | No | 209 (34.9) | 40 (33.1) | 0.587 | 36 (31) | 0.658 | 31 (31.3) | 0.718 | 48 (33.3) | 0.573 |
Yes | 194 (32.4) | 44 (36.4) | 40 (34.5) | 34 (34.3) | 47 (32.6) | |||||
Unknown | 195 (32.6) | 37 (30.6) | 40 (34.5) | 34 (34.3) | 49 (34) | |||||