Table 2 Demographics and clinicopathological features of GBM patients in the TCGA and CGGA cohort
Variables | TCGA cohort | CGGA cohort | ||||
|---|---|---|---|---|---|---|
Total (n = 518) | CDI low risk (n = 248) | CDI high risk (n = 270) | Total (n = 137) | CDI low risk (n = 66) | CDI high risk (n = 71) | |
Age (years) | 57.54 ± 14.60 | 55.30 ± 15.94 | 59.60 ± 12.95 | 46.61 ± 12.56 | 42.88 ± 11.30 | 50.08 ± 12.76 |
Gender | ||||||
  Male | 314 | 154 | 160 | 87 | 37 | 50 |
  Female | 204 | 94 | 110 | 50 | 29 | 21 |
Surgery | ||||||
  Tumor resection | 451 | 211 | 240 | NA | NA | NA |
Biopsy only | 65 | 36 | 29 | NA | NA | NA |
  NA | 2 | 1 | 1 | NA | NA | NA |
Pretreatment KPS | ||||||
   ≥ 80 | 286 | 151 | 135 | NA | NA | NA |
   < 80 | 101 | 41 | 60 | NA | NA | NA |
  NA | 131 | 56 | 75 | NA | NA | NA |
Radiotherapy | ||||||
  Yes | 402 | 207 | 195 | 100 | 47 | 53 |
  No | 94 | 33 | 61 | 32 | 19 | 13 |
  NA | 22 | 8 | 14 | 5 | 0 | 5 |
TMZ chemotherapy | ||||||
  Yes | 298 | 154 | 144 | 99 | 51 | 48 |
  No | 197 | 85 | 112 | 34 | 15 | 19 |
  NA | 23 | 9 | 14 | 4 | 0 | 4 |
Standard chemoradiotherapy | ||||||
  Yes | 199 | 101 | 98 | NA | NA | NA |
  No | 297 | 139 | 158 | NA | NA | NA |
  NA | 22 | 8 | 14 | NA | NA | NA |
TCGA subtype | ||||||
  Classical | 143 | 57 | 86 | NA | NA | NA |
  Mesenchymal | 152 | 40 | 112 | NA | NA | NA |
  Neural | 88 | 51 | 37 | NA | NA | NA |
  Proneural | 135 | 100 | 35 | NA | NA | NA |
G-CIMPstatus | ||||||
  G-CIMP | 45 | 44 | 1 | NA | NA | NA |
  Non G-CIMP | 473 | 204 | 269 | NA | NA | NA |
IDH status | ||||||
  Mutant | 30 | 29 | 1 | 39 | 37 | 2 |
  Wild type | 368 | 179 | 189 | 98 | 29 | 69 |
  NA | 120 | 40 | 80 | 0 | 0 | 0 |
MGMT promoter status | ||||||
  Methylated | 170 | 94 | 76 | 65 | 41 | 24 |
  Unmethylated | 177 | 69 | 108 | 70 | 24 | 46 |
  NA | 171 | 85 | 86 | 2 | 1 | 1 |
1p/19q status | ||||||
  Codeletion | NA | NA | NA | 7 | 7 | 0 |
  Non-codeletion | NA | NA | NA | 127 | 58 | 69 |
  NA | NA | NA | NA | 3 | 1 | 2 |
Overall Survival (OS) | ||||||
  > 3 years | 48 | 44 | 4 | 17 | 11 | 6 |
  ≤ 3 years | 470 | 204 | 266 | 120 | 55 | 65 |
OS status | ||||||
  Deceased | 441 | 203 | 238 | 124 | 59 | 65 |
  Living | 77 | 45 | 32 | 13 | 7 | 6 |
Progression-Free Survival (PFS) | ||||||
  > 3 years | 24 | 22 | 2 | NA | NA | NA |
 ≤ 3 years | 494 | 226 | 268 | NA | NA | NA |
PFS status | ||||||
  Progression | 442 | 201 | 241 | NA | NA | NA |
  No progression | 76 | 47 | 29 | NA | NA | NA |