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Table 2 Survival data of eligible studies

From: Additional capecitabine use in early-stage triple negative breast cancer patients receiving standard chemotherapy: a new era? A meta-analysis of randomized controlled trials

Study

Chemo-regimen

-Control arm

-X arm

TNBC NO.

-Control arm

-X arm

HR(95%CI) for Survival data(5-year evaluated)

X arm vs Control arm

Subgroup analysis in TNBC patients

OS

DFS

RFS

LRRFS

DMFS

USO 01062

-4 AC-4 T

-4 AC-4 TX

−384

−396

0.62 (0.41–0.94)

0.81 (0.57–1.15)

NS

NS

NS

NS

GEICAM/2003

-4EC-4 T

-4ET-4X

−71

−95

NS

1.19 (0.70–2.04)

NS

NS

NS

All LN positive

FinXX

-3 T-3CEF

-3TX-3CEX

−109

−93

NS

NS

0.53 (0.31–0.92)

NS

NS

NS

CREATE-X

-standard NACT

-standard NACT

+  6-8X

−147

−139

0.52 (0.30–0.90)

0.58 (0.39–0.87)

NS

NS

NS

NS

CIBOMA/2004

-standard CT

-standard CT

+ 8X

−428

−448

0.92 (0.66–1.28)

0.82 (0.63–1.06)

NS

NS

NS

LN status; menopausal status

CBCSG-010

-3 T-3CEF

-3TX-3CEX

−288

−297

0.67 (0.37–1.22)

0.66 (0.44–0.99)

0.59 (0.38–0.93)

NS

0.63 (0.39–1.00)

LN status; menopausal status

SYSUCC-001

-standard CT

-standard CT

+ X(1 year)

−213

−221

0.75 (0.47–1.19)

0.64 (0.42–0.95)

NS

0.72 (0.46–1.13)

0.60 (0.38–0.92)

LN status; menopausal status

  1. NS not shown