From: Nomograms to predict the prognosis in malignant ovarian germ cell tumors: a large cohort study
Variables | Univariate Cox Regression | Multivariate Cox Regression | ||||
---|---|---|---|---|---|---|
HR | 95%CI | P value | HR | 95%CI | P value | |
Age (years) | ||||||
≤ 27 | Reference | Reference | ||||
28–38 | 1.42 | 0.79–2.56 | 0.249 | 1.57 | 0.86–2.88 | 0.144 |
≥ 39 | 7.12 | 4.45–11.39 | < 0.001* | 5.70 | 3.34–9.73 | < 0.001* |
Tumor size (mm) | ||||||
≤ 130 | Reference | – | – | – | ||
131–175 | 0.81 | 0.48–1.39 | 0.458 | – | – | – |
≥ 176 | 0.73 | 0.45–1.21 | 0.222 | – | – | – |
FIGO Stage | ||||||
FIGO Stage I | Reference | Reference | ||||
FIGO Stage II | 2.56 | 1.05–6.24 | 0.039* | 1.96 | 0.78–4.90 | 0.151 |
FIGO Stage III | 4.54 | 2.68–7.69 | < 0.001* | 3.93 | 2.23–6.93 | < 0.001* |
FIGO Stage IV | 16.19 | 9.24–28.37 | < 0.001* | 8.11 | 4.26–15.45 | < 0.001* |
Laterality | ||||||
Only one side | Reference | Reference | ||||
Both sides | 3.14 | 1.51–6.50 | < 0.001* | 1.03 | 0.46–2.33 | 0.942 |
Unkown | 14.94 | 3.66–61.01 | < 0.001* | 1.19 | 0.26–5.34 | 0.825 |
Histological subtype | ||||||
Dysgerminoma | Reference | Reference | ||||
Yolk sac tumor | 5.41 | 2.60–11.28 | < 0.001* | 3.86 | 1.82–8.19 | < 0.001* |
Teratocarcinoma | 2.36 | 1.19–4.69 | 0.014* | 2.06 | 0.98–4.29 | 0.055 |
Non-gestational choriocarcinoma | 20.82 | 7.90–54.84 | < 0.001* | 3.82 | 1.24–11.75 | 0.020* |
Grade | ||||||
Grade I | Reference | Reference | ||||
Grade II | 8.18 | 1.06–63.37 | 0.044* | 5.82 | 0.74–45.69 | 0.094 |
Grade III | 10.30 | 1.37–77.12 | 0.023* | 6.06 | 0.79–46.61 | 0.084 |
Grade IV | 14.68 | 1.878–114.67 | 0.010* | 8.41 | 1.04–67.68 | 0.045* |
Unkown | 7.22 | 1.00–52.32 | 0.051 | 4.55 | 0.61–34.20 | 0.141 |
Surgery | ||||||
No | Reference | Reference | ||||
Local resection | 0.04 | 0.02–0.10 | < 0.001* | 0.18 | 0.07–0.49 | < 0.001* |
Debulking or cytoreductive surgery or pelvic exenteration | 0.16 | 0.07–0.37 | < 0.001* | 0.25 | 0.10–0.61 | 0.002* |
Radiation | ||||||
No | Reference | Reference | ||||
Yes | 11.12 | 4.50–27.51 | < 0.001* | 2.52 | 0.89–7.10 | 0.081 |
Chemotherapy | ||||||
No | Reference | – | – | – | ||
Yes | 1.29 | 0.83–2.01 | 0.256 | – | – | – |