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Table 2 The univariable and multivariate Cox regression analysis of overall survival

From: Nomograms to predict the prognosis in malignant ovarian germ cell tumors: a large cohort study

Variables Univariate Cox Regression Multivariate Cox Regression
HR 95%CI P value HR 95%CI P value
Age (years)
  ≤ 27 Reference   Reference  
 28–38 1.42 0.79–2.56 0.249 1.57 0.86–2.88 0.144
  ≥ 39 7.12 4.45–11.39 < 0.001* 5.70 3.34–9.73 < 0.001*
Tumor size (mm)
  ≤ 130 Reference  
 131–175 0.81 0.48–1.39 0.458
  ≥ 176 0.73 0.45–1.21 0.222
FIGO Stage
 FIGO Stage I Reference   Reference  
 FIGO Stage II 2.56 1.05–6.24 0.039* 1.96 0.78–4.90 0.151
 FIGO Stage III 4.54 2.68–7.69 < 0.001* 3.93 2.23–6.93 < 0.001*
 FIGO Stage IV 16.19 9.24–28.37 < 0.001* 8.11 4.26–15.45 < 0.001*
Laterality
 Only one side Reference   Reference  
 Both sides 3.14 1.51–6.50 < 0.001* 1.03 0.46–2.33 0.942
 Unkown 14.94 3.66–61.01 < 0.001* 1.19 0.26–5.34 0.825
Histological subtype
 Dysgerminoma Reference   Reference  
 Yolk sac tumor 5.41 2.60–11.28 < 0.001* 3.86 1.82–8.19 < 0.001*
 Teratocarcinoma 2.36 1.19–4.69 0.014* 2.06 0.98–4.29 0.055
 Non-gestational choriocarcinoma 20.82 7.90–54.84 < 0.001* 3.82 1.24–11.75 0.020*
Grade
 Grade I Reference   Reference  
 Grade II 8.18 1.06–63.37 0.044* 5.82 0.74–45.69 0.094
 Grade III 10.30 1.37–77.12 0.023* 6.06 0.79–46.61 0.084
 Grade IV 14.68 1.878–114.67 0.010* 8.41 1.04–67.68 0.045*
 Unkown 7.22 1.00–52.32 0.051 4.55 0.61–34.20 0.141
Surgery
 No Reference   Reference  
 Local resection 0.04 0.02–0.10 < 0.001* 0.18 0.07–0.49 < 0.001*
 Debulking or cytoreductive surgery or pelvic exenteration 0.16 0.07–0.37 < 0.001* 0.25 0.10–0.61 0.002*
Radiation
 No Reference   Reference  
 Yes 11.12 4.50–27.51 < 0.001* 2.52 0.89–7.10 0.081
Chemotherapy
 No Reference  
 Yes 1.29 0.83–2.01 0.256
  1. HR Hazard Ratio, CI Confidence Interval, FIGO Federation International of Gynecology and Obstetrics; *means p < 0.05