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Table 2 The univariable and multivariate Cox regression analysis of overall survival

From: Nomograms to predict the prognosis in malignant ovarian germ cell tumors: a large cohort study

Variables

Univariate Cox Regression

Multivariate Cox Regression

HR

95%CI

P value

HR

95%CI

P value

Age (years)

  ≤ 27

Reference

 

Reference

 

 28–38

1.42

0.79–2.56

0.249

1.57

0.86–2.88

0.144

  ≥ 39

7.12

4.45–11.39

< 0.001*

5.70

3.34–9.73

< 0.001*

Tumor size (mm)

  ≤ 130

Reference

 

 131–175

0.81

0.48–1.39

0.458

  ≥ 176

0.73

0.45–1.21

0.222

FIGO Stage

 FIGO Stage I

Reference

 

Reference

 

 FIGO Stage II

2.56

1.05–6.24

0.039*

1.96

0.78–4.90

0.151

 FIGO Stage III

4.54

2.68–7.69

< 0.001*

3.93

2.23–6.93

< 0.001*

 FIGO Stage IV

16.19

9.24–28.37

< 0.001*

8.11

4.26–15.45

< 0.001*

Laterality

 Only one side

Reference

 

Reference

 

 Both sides

3.14

1.51–6.50

< 0.001*

1.03

0.46–2.33

0.942

 Unkown

14.94

3.66–61.01

< 0.001*

1.19

0.26–5.34

0.825

Histological subtype

 Dysgerminoma

Reference

 

Reference

 

 Yolk sac tumor

5.41

2.60–11.28

< 0.001*

3.86

1.82–8.19

< 0.001*

 Teratocarcinoma

2.36

1.19–4.69

0.014*

2.06

0.98–4.29

0.055

 Non-gestational choriocarcinoma

20.82

7.90–54.84

< 0.001*

3.82

1.24–11.75

0.020*

Grade

 Grade I

Reference

 

Reference

 

 Grade II

8.18

1.06–63.37

0.044*

5.82

0.74–45.69

0.094

 Grade III

10.30

1.37–77.12

0.023*

6.06

0.79–46.61

0.084

 Grade IV

14.68

1.878–114.67

0.010*

8.41

1.04–67.68

0.045*

 Unkown

7.22

1.00–52.32

0.051

4.55

0.61–34.20

0.141

Surgery

 No

Reference

 

Reference

 

 Local resection

0.04

0.02–0.10

< 0.001*

0.18

0.07–0.49

< 0.001*

 Debulking or cytoreductive surgery or pelvic exenteration

0.16

0.07–0.37

< 0.001*

0.25

0.10–0.61

0.002*

Radiation

 No

Reference

 

Reference

 

 Yes

11.12

4.50–27.51

< 0.001*

2.52

0.89–7.10

0.081

Chemotherapy

 No

Reference

 

 Yes

1.29

0.83–2.01

0.256

  1. HR Hazard Ratio, CI Confidence Interval, FIGO Federation International of Gynecology and Obstetrics; *means p < 0.05