Table 3 GKRS treatment outcomes in the primary GKRS, postoperative GKRS and combined group
Outcomes | Primary GKRS, n = 61, (%) | Postoperative GKRS, n = 61, (%) | P value | Combined group, n = 122, (%) |
|---|---|---|---|---|
Radiological outcomes | NA | NA | NA | NA |
Tumor control | 47 (77.0) | 41 (67.2) | NA | 88 (72.1) |
Tumor shrinkage | 32 | 31 | NA | 63 (51.6) |
Stable tumor | 15 | 10 | NA | 25 (20.5) |
Progression | 14 (23.0) | 20 (32.8) | 0.403 | 34 (27.9) |
Distant failure | 5 (8.2) | 8 (13.1) | 0.480 | 13 (10.7) |
GKRS related adverse effects | 16 (26.2) | 9 (14.8) | 0.138 | 25 (20.5) |
Radiation-induced edema | 14 (23.0) | 7 (11.5) | 0.102 | 21 (17.2) |
Symptomatic | 5 | 2 | NA | 7 |
Asymptomatic | 9 | 5 | NA | 14 |
Clinical outcomes | NA | NA | NA | NA |
Improvement | 11 | 7 | NA | 18 |
Stable | 33 | 40 | NA | 73 |
Clinical progression | 17 (27.9) | 14 (23.0) | 0.336 | 31 (25.4) |
CN dysfunction | 10 | 6 | NA | 16 |
I | 1 | 0 | NA | 1 |
II | 4 | 3 | NA | 7 |
III/IV/VI | 6 | 1 | NA | 7 |
V | 4 | 2 | NA | 6 |
VII | 1 | 1 | NA | 2 |
VIII | 0 | 1 | NA | 1 |
Headache | 5 | 4 | NA | 9 |
Seizures | 4 | 2 | NA | 6 |
Extremity numbness | 2 | 1 | NA | 3 |
Extremity weakness | 1 | 2 | NA | 3 |
Memory decline | 1 | 1 | NA | 2 |