Table 3 SMPDB pathway enrichment

Phenylacetate Metabolism

9

0.132

2

0.0068

0.666

0.666

AMP; Phenylacetic acid

Propanoate Metabolism

42

0.615

2

0.123

1

1

AMP; Hydroxypropionic acid

Fatty acid Metabolism

43

0.63

2

0.128

1

1

AMP; Palmitoylcarnitine

Pyruvate Metabolism

48

0.703

2

0.153

1

1

AMP; Lactic acid

Arginine and Proline Metabolism

53

0.776

2

0.18

1

1

AMP; Proline

Glycine and Serine Metabolism

59

0.864

2

0.212

1

1

AMP; 5-Aminolevulinic acid

Bile Acid Biosynthesis

65

0.952

2

0.246

1

1

CDCA; GCDCA

Thiamine Metabolism

9

0.132

1

0.125

1

1

AMP

Alanine Metabolism

17

0.249

1

0.223

1

1

AMP

Butyrate Metabolism

19

0.278

1

0.246

1

1

AMP

Ethanol Degradation

19

0.278

1

0.246

1

1

AMP

Ubiquinone Biosynthesis

20

0.293

1

0.258

1

1

4-Hydroxybenzoic acid

Riboflavin Metabolism

20

0.293

1

0.258

1

1

AMP

Pantothenate and CoA Biosynthesis

21

0.308

1

0.269

1

1

AMP

Cysteine Metabolism

26

0.381

1

0.322

1

1

AMP

Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids

27

0.396

1

0.332

1

1

AMP

Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids

27

0.396

1

0.332

1

1

AMP

Phenylalanine and Tyrosine Metabolism

28

0.41

1

0.342

1

1

AMP

Selenoamino Acid Metabolism

28

0.41

1

0.342

1

1

AMP

Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids

28

0.41

1

0.342

1

1

AMP

Pentose Phosphate Pathway

29

0.425

1

0.352

1

1

AMP

Urea Cycle

29

0.425

1

0.352

1

1

AMP

Ammonia Recycling

32

0.469

1

0.381

1

1

AMP

Aspartate Metabolism

35

0.513

1

0.409

1

1

AMP

Gluconeogenesis

35

0.513

1

0.409

1

1

Lactic acid

Fatty Acid Biosynthesis

35

0.513

1

0.409

1

1

Myristic acid

Nicotinate and Nicotinamide Metabolism

37

0.542

1

0.426

1

1

AMP

Porphyrin Metabolism

40

0.586

1

0.452

1

1

5-Aminolevulinic acid

Methionine Metabolism

43

0.63

1

0.477

1

1

AMP

Histidine Metabolism

43

0.63

1

0.477

1

1

AMP

Glutamate Metabolism

49

0.718

1

0.523

1

1

AMP

Warburg Effect

58

0.85

1

0.586

1

1

Lactic acid

Purine Metabolism

74

1.08

1

0.678

1

1

AMP