Table 3 Univariate and multivariate Cox proportional hazards models for DFS

Univariate

Sex

 Male

1.335 (0.832–2.140)

1.024 (0.465–2.253)

 Female

1

1

Segment

 Proximal

1

1

 Body

0.990(0.840–1.167)

0.840(0.559–1.263)

 Distal

0.951(0.723–1.098)

0.845(0.650–1.099)

Pathological type

 Well differentiated

1

–

 Moderate differentiated

1.000(0.561–1.652)

1

 Poorly differentiated

1.001(0.652–1.623)

1.465(0.933–2.302)

 Mucinous adenocarcinoma

1.986(0.968–3.632)

1.235(0.873–1.748)

 Signet ring cell carcinoma

1.020(0.862–1.774)

1.149(0.686–1.603)

T stage

 T1

1

–

 T2

1.057(0.656–1.703)

1

 T3

1.184(0.783–1.805)

1.489(0.430–6.744)

 T4

1.357(0.856–2.013)

1.815(0.657–5.017)

N stage

 N0

1

1

 N1

1.170(0.505–2.710)

1.186(0.672–2.092)

 N2

1.234(0.778–1.655)

1.279(0.781–2.181)

 N3

1.338(1.061–1.689)

1.307(0.962–1.777)

Surgical procedure

 D1

1.230(0.685–2.207)

1.423(0.532–3.805)

 D1+

1.091(0.569–2.091)

1.119(0.524–2.392)

 D2

1

1

 No operation

1.213(1.106–1.331)

–

Peri-operative chemo.

 Yes

1

1

 No

1.005(0.630–1.807)

1.202(0.754–2.244)

CRT timing

 Pre-

1

1

 Post-

1.000(0.636–1.575)

2.127(1.010–4.420)

Multivariate

T stage

 T1

1

 T2

1.149(0.712–1.889)

 T3

1.184(0.783–1.905)

 T4

1.151(0.479–1.439)

N stage

 N0

1

1

 N1

1.772(0.946–1.812)

1.379(0.661–3.370)

 N2

2.059(1.039–2.211)

1.648(0.872–4.549)

 N3

2.565(1.526–2.699)

1.307(0.806–7.008)

Surgical procedure

 D1

1.520(0.997–3.237)

 D1+

1.290(1.047–1.446)

 D2

1

 No operation

2.213(0.881–5.440)

CRT timing

 Pre-

1

 Post-

2.114(1.291–8.140)