Co-deficiency of B7-H3 and B7-H4 identifies high CD8 + T cell infiltration and better prognosis in pancreatic cancer

Si, Shuping; Wang, Lei; Cao, Hui; Xu, Yuhua; Zhan, Qiang

doi:10.1186/s12885-022-09294-w

Table 2 Differences of immune cells levels estimated by xCell algorithm

From: Co-deficiency of B7-H3 and B7-H4 identifies high CD8 + T cell infiltration and better prognosis in pancreatic cancer

Immune cells	Average			F value	P value
Immune cells	co-low	single-high	co-high	F value	P value
aDC	0.080	0.108	0.097	2.582	0.079
Adipocytes	0.108	0.076	0.031	3.456	0.034
Astrocytes	0.040	0.087	0.106	13.338	0.000
B cells	0.108	0.111	0.062	0.538	0.585
Basophils	0.038	0.012	0.007	6.142	0.003
CD4 + memory T cells	0.137	0.125	0.107	1.028	0.360
CD4 + naïve T cells	0.060	0.064	0.045	0.577	0.563
CD4 + T cells	0.004	0.002	0.000	0.622	0.538
CD4 + Tcm	0.006	0.004	0.003	2.194	0.115
CD4 + Tem	0.014	0.011	0.011	0.850	0.429
CD8 + naïve T cells	0.008	0.009	0.007	1.943	0.146
CD8 + T cells	0.034	0.015	0.011	10.264	0.000
CD8 + Tcm	0.022	0.014	0.010	3.071	0.049
CD8 + Tem	0.003	0.002	0.000	2.196	0.114
cDC	0.026	0.022	0.019	0.701	0.498
Chondrocytes	0.126	0.161	0.163	4.418	0.013
Class switched memory B cells	0.034	0.025	0.020	1.493	0.228
CLP	0.048	0.042	0.044	1.146	0.320
CMP	0.000	0.000	0.000	1.071	0.345
DC	0.060	0.071	0.056	1.160	0.316
Endothelial cells	0.142	0.143	0.145	0.010	0.990
Eosinophils	0.030	0.036	0.038	3.502	0.032
Epithelial cells	0.726	0.891	0.918	7.364	0.001
Erythrocytes	0.000	0.000	0.000	0.943	0.391
Fibroblasts	0.121	0.138	0.137	0.559	0.573
GMP	0.004	0.002	0.000	2.493	0.086
Hepatocytes	0.085	0.090	0.098	0.516	0.598
HSC	0.196	0.221	0.215	1.009	0.367
iDC	0.119	0.131	0.114	0.591	0.555
Keratinocytes	0.092	0.137	0.142	5.336	0.006
Ly Endothelial cells	0.154	0.157	0.154	0.016	0.984
Macrophages	0.054	0.074	0.072	2.933	0.056
Macrophages M1	0.046	0.065	0.065	5.435	0.005
Macrophages M2	0.015	0.017	0.013	1.055	0.350
Mast cells	0.032	0.029	0.024	3.281	0.040
Megakaryocytes	0.014	0.014	0.012	1.286	0.279
Melanocytes	0.013	0.012	0.011	0.447	0.640
Memory B cells	0.015	0.016	0.009	0.305	0.738
MEP	0.035	0.030	0.027	1.792	0.170
Mesangial cells	0.081	0.093	0.106	8.969	0.000
Monocytes	0.021	0.033	0.021	2.337	0.100
MPP	0.000	0.000	0.000	0.056	0.945
MSC	0.140	0.265	0.310	28.875	0.000
Mv Endothelial cells	0.052	0.057	0.059	0.483	0.618
Myocytes	0.006	0.005	0.004	1.011	0.366
Naïve B cells	0.010	0.013	0.007	0.398	0.672
Neurons	0.066	0.015	0.014	17.406	0.000
Neutrophils	0.001	0.001	0.001	0.094	0.910
NK cells	0.000	0.000	0.000	0.458	0.633
NKT	0.024	0.022	0.026	0.959	0.385
Osteoblast	0.077	0.036	0.034	10.543	0.000
pDC	0.072	0.058	0.046	1.981	0.141
Pericytes	0.074	0.099	0.115	3.779	0.025
Plasma cells	0.011	0.008	0.005	6.987	0.001
Platelets	0.001	0.000	0.000	7.379	0.001
Preadipocytes	0.009	0.002	0.001	3.916	0.022
Pro B cells	0.002	0.002	0.001	0.319	0.727
Sebocytes	0.408	0.533	0.534	4.005	0.020
Skeletal muscle	0.000	0.000	0.000	2.332	0.100
Smooth muscle	0.386	0.332	0.333	12.517	0.000
Tgd cells	0.000	0.000	0.000	0.263	0.769
Th1 cells	0.058	0.046	0.047	1.671	0.191
Th2 cells	0.009	0.010	0.009	0.041	0.960
Tregs	0.016	0.011	0.009	3.210	0.043

Abbreviations: aDC Activated dendritic cells, CD4 + Tcm, CD4 + central memory T-cells, CD4 + Tem CD4 + effector memory T-cells, CD8 + Tcm CD8 + central memory T-cells, CD8 + Tem CD8 + effector memory T-cells, cDC Xonventional dendritic cells, CLP Common lymphoid progenitors, CMP Common myeloid progenitors, DC Dendritic cells, GMP Granulocyte–macrophage progenitors, HSC Hematopoietic stem cells, iDC Immature dendritic cells, ly endothelial cells Lymphatic endothelial cells, MEP Megakaryocyte–erythroid progenitors, MPP Multipotent rogenitors, MSC Mesenchymal stem cells, mv endothelial cells Microvascular endothelial cells, NKT Natural killer T-cells, pDC Plasmacytoid dendritic cells, Tgd cells Gamma delta T-cells, Th1 cells Type 1 T-helper cells, Th2 cells Type 2 T-helper cells, Tregs Regulatory T-cells

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ISSN: 1471-2407

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