Fig. 2

Age-varying effects on all-cause mortality in BCLC stage 0-B and BCLC stage C-D. HR and 95% confidence intervals were derived from a Cox proportional hazards regression model with restricted cubic splines, with 6 knots at 30, 40, 50, 60, 70, and 80 years of age. Reference age was 45 years. The red line and red area indicated HR and 95% CI of BCLC stage 0-B, and the blue line and blue area indicated HR and 95% CI of BCLC stage C-D. HR, hazard ratios; CI, confidence interval; BCLC, Barcelona Clinic Liver Cancer