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Fig. 7 | BMC Cancer

Fig. 7

From: Tenascin-C promotes bladder cancer progression and its action depends on syndecan-4 and involves NF-κB signaling activation

Fig. 7

Summary of the present investigation. In the BCa microenvironment, TN-C may be secreted by diverse cells including tumor cells and other mesenchymal cells, e.g., fibroblast cells, etc. Thus, the secreted TN-C binds to the membrane receptor syndecan-4 and a critical downstream factor for this is NF-κB signaling. Binding of TN-C to syndecan-4 leads to activation of NF-κB signaling and subsequent enhanced ability of cells to migrate, invade, and proliferate as well as cause EMT. However, how syndecan-4 activates NF-κB signaling is not known

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