Table 3 Univariate and multivariate analyses of disease-free interval

Age (≥ 65 vs. < 65)

1.09(0.76,1.54)

0.65

-

-

Gender (Female vs. Male)

0.88(0.61,1.27)

0.487

-

-

Family history of cancer (Yes vs. No)

0.92(0.63,1.36)

0.683

-

-

TNM stage (II vs. I)

1.7(1.12,2.6)

0.014

1.78(1.05,3.02)

0.032

TNM stage (III vs. I)

2.84(1.89,4.26)

< 0.001

2.73(1.65,4.52)

< 0.001

TNM stage (IV vs. I)

-

-

-

-

Histologic grade (G3–G4 vs. G1–G2)

1.26(0.89,1.77)

0.197

-

-

Ishak score (5–6 vs. 0–4)

1.32(0.87,2.01)

0.196

-

-

Child–Pugh grade (B–C vs. A)

1.43(0.74,2.76)

0.287

-

-

Vascular invasion (Micro vs. None)

1.35(0.89,2.05)

0.161

0.92(0.56,1.5)

0.735

Vascular invasion (Macro vs. None)

2.82(1.34,5.92)

0.006

2.4(1.12,5.18)

0.025

Alpha fetoprotein (Positive vs. Negative)

1.08(0.74,1.59)

0.691

-

-

Residual tumor (R1–R2 vs. R0)

-

-

-

-

POLD1 (High vs. Low)

1.36(1.08,1.71)

0.01

1.29(0.99,1.68)

0.057