Fig. 5

Exploration for underlying mechanisms of POLD1 overexpression in HCC. A Comparison of POLD1 mRNA expression in different copy number alteration (CNA) groups. B Correlation analysis between POLD1 DNA methylation and its mRNA expression. C Correlation analysis between miR-139-3p expression and POLD1 mRNA expression. D Comparison of miR-139-3p expression in HCC (n = 370) and in normal liver samples (n = 50). Kaplan-Meier curves of overall survival E and disease-free interval F for patients with high and low miR-139-3p expression levels. G The putative binding site of POLD1 3’ UTR by miR-139-3p. (Quasi-likelihood F-test, P < 0.05 was considered significant, * P < 0.05, ** P < 0.01, *** P < 0.001)